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Richard Radcliffe Publications

Refereed Journals

Erwin, V. G., Jones, B. C. and Radcliffe, R. Further characterization of LS X SS recombinant inbred strains of mice: Activating and hypothermic effects of ethanol. Alcohol Clin Exp Res 14:200-204, 1990.

Erwin, V. G., Jones, B. C. and Radcliffe, R. Low doses of ethanol reduce neurotensin levels in discrete brain regions from LS/lbg and SS/lbg mice. Alcohol Clin Exp Res 14:42-47, 1990.

Jones, B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. Cocaine actions, brain levels and receptors in selected lines of mice. Pharmacol Biochem Behav 40:941-948, 1991.

Erwin, V. G., Radcliffe, R. and Jones, B. C. Chronic ethanol consumption produces genotype-dependent tolerance to ethanol in LS/lbg and SS/lbg mice. Pharmacol Biochem Behav 41:275-281, 1992.

Erwin, V. G., Campbell, A. D. and Radcliffe, R. A. Effects of chronic ethanol administration on neurotensinergic processes: Correlations with tolerance in LS and SS mice. Ann NY Acad Sci 654:441-443, 1992.

Jones, B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. Psychomotor stimulant effect of cocaine is affected by genetic makeup and experimental history. Ann NY Acad Sci 654:456-458, 1992.

Jones, B. C., Reed, C. L., Radcliffe, R. A. and Erwin, V. G. Pharmacogenetics of cocaine: I. Locomotor activity and self-selection in C57BL and DBA mice. Pharmacogenetics 3:182-188, 1993.

Erwin, V. G., Radcliffe, R. A., Hinkle, B. and Jones, B. C. Genetic-based differences in neurotensin levels and receptors in brains of LSXSS mice. Peptides 14:821-828, 1993.

Erwin, V. G. and Radcliffe, R. A. Characterization of neurotensin-stimulated phosphatidylinositol hydrolysis in brain regions of LS and SS mice. Brain Res 629:59-66, 1994.

Radcliffe, R. A. and Erwin, V. G. Alterations in locomotor activity following microinjections of GBR-12909, selective dopamine antagonists, or neurotensin into the medial prefrontal cortex. J Pharmacol Exp Ther 277:1467-1476, 1996.

Erwin, V. G., Radcliffe, R. A., Gehle, V. M., and Jones, B. C. Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: Locomotor activation. J Pharmacol Exp Ther 280:919-926, 1997.

Wehner, J. M., Radcliffe, R. A., Rosman, S. T., Christensen, S. C., Rasmussen, D. L., Fulker, D. F., and Wiles, M. Quantitative trait loci analysis of contextual fear conditioning in C57BL/6J X DBA/2J F2 mice. Nature Genet 17:331-334, 1997.

Radcliffe, R. A., Jones, B. C., and Erwin, V. G. Mapping of provisional quantitative trait loci influencing temporal variation in locomotor activity in the LSXSS recombinant inbred strains. Behav Genet 28:39-47, 1998.

Radcliffe, R. A., Walter, N. A. R., Sikela, J. M., and Erwin, V. G. Discovery of a new Pomc1 allele in the LSXSS recombinant inbred strains: Relationship to locomotor behavior. Behav Genet 28:49-55, 1998.

Radcliffe, R. A. and Erwin, V. G. Genetic relationship between central b-endorphin and novelty-induced locomotor activity. Pharmacol Biochem Behav 60:709-718, 1998.

Radcliffe, R. A., Erwin, V. G., and Wehner, J. M. Acute functional tolerance to ethanol and fear conditioning are genetically correlated in mice. Alcohol Clin Exp Res 22:1673-1679, 1998.

Turri, M. G., Talbot, C. J., Radcliffe, R. A., Wehner, J. M., and Flint, J. High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mamm Genome 10:1098-1101,1999.

Radcliffe, R. A., Lowe, M. V., and Wehner, J. M. Confirmation of contextual fear conditioning QTLs by short-term selection. Behav Genet 30:183-191, 2000.

Wick, M. J., Radcliffe, R. A., Bowers, B. J., Mascia, M. P., Lüscher, B., Harris, R. A., and Wehner, J. M. Behavioral changes produced by transgenic overexpression of ─L and ─S subunits of the GABAA receptor. Eur J Neurosci 12:2634-2638, 2000.

Radcliffe, R. A., Bohl, M. L., Lowe, M. V., Cycowski, C. S., and Wehner, J. M. Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains. Alcohol Clin Exp Res 24: 1335-1342, 2000.

Vissel, B., Royle, G. A., Christie, B. R., Schiffer, H.H., Ghetti, A., Tritto, T., Perez-Otano, I., Radcliffe, R. A., Seamens, J., Sejnowski, T., Wehner, J. M., Collins, A. C., O’Gorman, S., and Heinemann, S. F. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29: 217-227, 2001.

Erwin, V. G., Radcliffe, R. A., and Deitrich, R. A. Neurotensin levels in specific brain regions and hypnotic sensitivity to ethanol and pentobarbital as a function of time after haloperidol administration in selectively-bred rat lines. J Pharmacol Exp Ther 299: 698-704, 2001.

Erwin, V. G., Gehle, V. M., Davidson, K. L., and Radcliffe, R. A. Correlations and common quantitative trait loci between neurotensin receptor density and hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 25:1699-1707, 2001.

Malkinson, A. M., Radcliffe, R. A., and Bauer, A. K. Quantitative trait locus (QTL) mapping of susceptibilities to butylated hydroxytoluene (BHT)-induced lung tumor promotion and pulmonary inflammation in CXB mice. Carcinogenesis 23:411-417, 2002.

Balogh, S. A., Radcliffe, R. A., Logue, S. F., and Wehner, J. M. Contextual fear conditioning in C57BL/6J and DBA/2J mice: context discrimination and the effects of retention interval. Behav Neurosci 116:947-957, 2002.

Talbot, C. J., Radcliffe, R. A., Fullerton, J., Hitzemann, R, Wehner, J. M., and Flint, J. Fine scale mapping of a genetic locus for conditioned fear. Mamm Genome 14:223-230, 2003.

Bernert, H., Sekikawa, K., Radcliffe, R. A., Iraqi, F., You, M., and Malkinson, A. M Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog 38:117-123, 2003.

Radcliffe, R. A., Hoffmann, S. E., Deng, X-S., Asperi, W., Fay, T., Bludeau, P., Erwin, V. G., and Deitrich, R. A. Behavioral characterization of Alcohol-tolerant and Alcohol-nontolerant rat lines and an F2 generation. Behav Genet Submitted, 2003.

Radcliffe, R. A., Bowers, B. J., Smith, A. M., and Wehner, J. M. Transcriptional Profiling of the Cerebellum from PKCg Null Mutant Mice. J Neurochem Submitted, 2003.


Review Articles

Wehner, J. M., Radcliffe, R. A., and Bowers, B. J. Quantitative genetics and mouse behavior. Ann Rev Neurosci 24: 845-867, 2001.


Book Chapters

Deitrich, R. A., Radcliffe, R. A. and Erwin, V. G. (1996) Pharmacological effects in the development of tolerance and physical dependence. In The Pharmacology of Alcohol and Alcohol Dependence, Begleiter, H. and Kissin, B., eds. New York: Oxford University Press, chapter 11, pp. 431-476.

Wehner, J. M. and Radcliffe, R. A. (2001) Cued and Contextual Fear Conditioning in Mice. In Current Protocols in Neuroscience, Crawley, J., ed. New York: J. Wiley, chapter 8.

Wehner, J. M. and Radcliffe, R. A. (2003) Cued and Contextual Fear Conditioning in Mice. (updated version) In Current Protocols in Neuroscience, Crawley, J., ed. New York: J. Wiley, chapter 8.


Abstracts/Presentations

Erwin, V. G., Jones, B. C. and Radcliffe, R. A. (1990) Calcium-dependent stimulation of phosphoinositide hydrolysis by neurotensin in brain slices from long-sleep and short-sleep mice. Alcohol Clin Exp Res 14: 287.

Erwin, V. G., Iozzo, T. M., Campbell, A. D. and Radcliffe, R. (1991) Characterization of genotype-dependent acquisition of chronic tolerance and/or sensitization to ethanol-induced locomotor activation. Alcohol Clin Exp Res 15: 331.

Erwin, V. G., Jones, B. C. and Radcliffe, R. A. (1991) Genetic correlations among neurotensin levels and receptors and ethanol?related behaviors in LSXSS recombinant inbred strains of mice. Alcohol Clin Exp Res 15: 322.

Jones, B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. (1991) Pharmacogenetic analysis of cocaine in mice: Behavior and neurochemistry. FASEB J 5: A1561.

Jones, B. C., Radcliffe, R. A., Campbell, A. D. and Erwin, V. G. (1991) Low-dose ethanol effects: Correlated responses in recombinant inbred mice. Alcohol Clin Exp Res 15: 319.

Radcliffe, R. A. and Erwin, V. G. (1991) Ethanol enhances neurotensin-induced stimulation of inositol phospholipid metabolism. Society for Neuroscience Abstracts 17: 422.

Radcliffe, R. A. and Erwin, V. G. (1993) Internalization of neurotensin receptor-ligand complex in microsacs isolated from murine brain. Society for Neuroscience Abstracts 19: 298.15.

Radcliffe, R. A. and Erwin, V. G. (1994) Neurotensin reverses locomotor inhibition produced by microinjections of GBR-12909 into the medial prefrontal cortex. Society for Neuroscience Abstracts 20: 553.11.

Erwin, V. G., Jones, B. C., and Radcliffe, R. A. (1994) Neurotensin receptor densities correlate with ethanol induced locomotor activation in LS, SS, and LSXSS RI strains of mice. Alcohol Clin Exp Res 14: 480.

Radcliffe, R. A. and Erwin, V. G. (1995) Stimulation of dopamine receptors in the medial prefrontal cortex mediates inhibition of spontaneous locomotor activity. Society for Neuroscience Abstracts 21: 662.18.

Radcliffe, R. A., Walter, N. A. R., Jones, B. C., Sikela, J. M., and Erwin, V. G. (1997) QTL and the candidate gene approach: A cautionary tale. Alcohol Clin Exp Res 21: 93.

Radcliffe, R. A. and Wehner, J. M. (1997) Temporal analyses of contextual fear conditioning: Further characterization of differences between C57BL/6 and DBA/2J mice. Society for Neuroscience Abstracts 23: 822.1.

Owen, E. H., Radcliffe, R. A., Rosmann, S. T., Christensen, S. C., and Wehner, J. M. (1997) Mapping of genes regulating contextual fear conditioning in mice. Society for Neuroscience Abstracts 23: 822.4.

Radcliffe, R. A., Erwin, V. G., and Wehner, J. M. (1998) Genetic correlation between fear conditioning and acute functional tolerance to alcohol. Alcohol Clin Exp Res 22: 306.

Radcliffe, R. A. and Wehner, J. M. (1999) Gene-environment interactions influence differences in acute ethanol tolerance in B6 and D2 mice. Alcohol Clin Exp Res, 23: 330.

Erwin, V. G., Gehle, V. M., Davidson, K. L., and Radcliffe, R. A. (2000) Correlations and common quantitative trait loci between neurotensin receptor density and hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 24: 535.

Malkinson, A. M., Radcliffe, R. A., Bauer A., and Dwyer-Nield, L. D. (2001) QTLs that regulate susceptibility to the chronic pulmonary inflammation and lung tumor promotion induced by butylated hydroxytoluene (BHT). American Association for Cancer Research Special Oncogenomics Conference.

Hoffmann, S. E., Radcliffe, R. A., Deng, X-S., Fay, T., Salaz, D., Bludeau, P., and Deitrich, R. A. (2002) The re-establishment, characterization and inbreeding of Alcohol-Tolerant and Alcohol-Nontolerant Rat lines. Alcohol Clin Exp Res 26:575.

Radcliffe, R. A., Hoffmann, S. E., Laster, E. W., Deng, X-S., Bludeau, P., Erwin, V. G., and Deitrich, R. A. (2002) QTL mapping for acute tolerance and hypnotic sensitivity to ethanol in an F2 derived from inbred high and low alcohol sensitivity rats. Alcohol Clin Exp Res 26:576.

Radcliffe, R. A., Hoffmann, S. E., Deng, X-S, Bludeau, P., Fay, T., Asperi, W., Erwin, V. G., and Deitrich, R. A. (2003) Inbreeding of Alcohol-tolerant (AT) and Alcohol-nonteolerant (ANT) rat lines and characterization of an F2 population. Alcohol Clin Exp Res

Radcliffe, R. A., Miyamoto, J., Wehner, J. M. (2003) Fine Mapping of a Chromosome 1 QTL for Fear Conditioning Using the Congenic Strategy Reveals Multiple QTL. QTL to Gene: New strategies & recent progress for alcohol-related behaviors.


Other Publications

Radcliffe, R. A. DOPS retreat celebrates research diversity, success stories. School of Pharmacy News Fall 2003

 

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