Richard
Radcliffe Publications
Refereed Journals
Erwin, V. G., Jones, B. C. and Radcliffe, R. Further characterization
of LS X SS recombinant inbred strains of mice: Activating and hypothermic
effects of ethanol. Alcohol Clin Exp Res 14:200-204, 1990.
Erwin, V. G., Jones, B. C. and Radcliffe, R. Low doses of ethanol
reduce neurotensin levels in discrete brain regions from LS/lbg and
SS/lbg mice. Alcohol Clin Exp Res 14:42-47, 1990.
Jones, B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. Cocaine
actions, brain levels and receptors in selected lines of mice. Pharmacol
Biochem Behav 40:941-948, 1991.
Erwin, V. G., Radcliffe, R. and Jones, B. C. Chronic ethanol consumption
produces genotype-dependent tolerance to ethanol in LS/lbg and SS/lbg
mice. Pharmacol Biochem Behav 41:275-281, 1992.
Erwin, V. G., Campbell, A. D. and Radcliffe, R. A. Effects of chronic
ethanol administration on neurotensinergic processes: Correlations
with tolerance in LS and SS mice. Ann NY Acad Sci 654:441-443, 1992.
Jones, B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. Psychomotor
stimulant effect of cocaine is affected by genetic makeup and experimental
history. Ann NY Acad Sci 654:456-458, 1992.
Jones, B. C., Reed, C. L., Radcliffe, R. A. and Erwin, V. G. Pharmacogenetics
of cocaine: I. Locomotor activity and self-selection in C57BL and
DBA mice. Pharmacogenetics 3:182-188, 1993.
Erwin, V. G., Radcliffe, R. A., Hinkle, B. and Jones, B. C. Genetic-based
differences in neurotensin levels and receptors in brains of LSXSS
mice. Peptides 14:821-828, 1993.
Erwin, V. G. and Radcliffe, R. A. Characterization of neurotensin-stimulated
phosphatidylinositol hydrolysis in brain regions of LS and SS mice.
Brain Res 629:59-66, 1994.
Radcliffe, R. A. and Erwin, V. G. Alterations in locomotor activity
following microinjections of GBR-12909, selective dopamine antagonists,
or neurotensin into the medial prefrontal cortex. J Pharmacol Exp
Ther 277:1467-1476, 1996.
Erwin, V. G., Radcliffe, R. A., Gehle, V. M., and Jones, B. C. Common
quantitative trait loci for alcohol-related behaviors and central
nervous system neurotensin measures: Locomotor activation. J Pharmacol
Exp Ther 280:919-926, 1997.
Wehner, J. M., Radcliffe, R. A., Rosman, S. T., Christensen, S. C.,
Rasmussen, D. L., Fulker, D. F., and Wiles, M. Quantitative trait
loci analysis of contextual fear conditioning in C57BL/6J X DBA/2J
F2 mice. Nature Genet 17:331-334, 1997.
Radcliffe, R. A., Jones, B. C., and Erwin, V. G. Mapping of provisional
quantitative trait loci influencing temporal variation in locomotor
activity in the LSXSS recombinant inbred strains. Behav Genet 28:39-47,
1998.
Radcliffe, R. A., Walter, N. A. R., Sikela, J. M., and Erwin, V. G.
Discovery of a new Pomc1 allele in the LSXSS recombinant inbred strains:
Relationship to locomotor behavior. Behav Genet 28:49-55, 1998.
Radcliffe, R. A. and Erwin, V. G. Genetic relationship between central
b-endorphin and novelty-induced locomotor activity. Pharmacol Biochem
Behav 60:709-718, 1998.
Radcliffe, R. A., Erwin, V. G., and Wehner, J. M. Acute functional
tolerance to ethanol and fear conditioning are genetically correlated
in mice. Alcohol Clin Exp Res 22:1673-1679, 1998.
Turri, M. G., Talbot, C. J., Radcliffe, R. A., Wehner, J. M., and
Flint, J. High-resolution mapping of quantitative trait loci for emotionality
in selected strains of mice. Mamm Genome 10:1098-1101,1999.
Radcliffe, R. A., Lowe, M. V., and Wehner, J. M. Confirmation of contextual
fear conditioning QTLs by short-term selection. Behav Genet 30:183-191,
2000.
Wick, M. J., Radcliffe, R. A., Bowers, B. J., Mascia, M. P., Lüscher,
B., Harris, R. A., and Wehner, J. M. Behavioral changes produced by
transgenic overexpression of ─L and ─S subunits of the GABAA
receptor. Eur J Neurosci 12:2634-2638, 2000.
Radcliffe, R. A., Bohl, M. L., Lowe, M. V., Cycowski, C. S., and Wehner,
J. M. Mapping of quantitative trait loci for hypnotic sensitivity
to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains.
Alcohol Clin Exp Res 24: 1335-1342, 2000.
Vissel, B., Royle, G. A., Christie, B. R., Schiffer, H.H., Ghetti,
A., Tritto, T., Perez-Otano, I., Radcliffe, R. A., Seamens, J., Sejnowski,
T., Wehner, J. M., Collins, A. C., O’Gorman, S., and Heinemann,
S. F. The role of RNA editing of kainate receptors in synaptic plasticity
and seizures. Neuron 29: 217-227, 2001.
Erwin, V. G., Radcliffe, R. A., and Deitrich, R. A. Neurotensin levels
in specific brain regions and hypnotic sensitivity to ethanol and
pentobarbital as a function of time after haloperidol administration
in selectively-bred rat lines. J Pharmacol Exp Ther 299: 698-704,
2001.
Erwin, V. G., Gehle, V. M., Davidson, K. L., and Radcliffe, R. A.
Correlations and common quantitative trait loci between neurotensin
receptor density and hypnotic sensitivity to ethanol. Alcohol Clin
Exp Res 25:1699-1707, 2001.
Malkinson, A. M., Radcliffe, R. A., and Bauer, A. K. Quantitative
trait locus (QTL) mapping of susceptibilities to butylated hydroxytoluene
(BHT)-induced lung tumor promotion and pulmonary inflammation in CXB
mice. Carcinogenesis 23:411-417, 2002.
Balogh, S. A., Radcliffe, R. A., Logue, S. F., and Wehner, J. M. Contextual
fear conditioning in C57BL/6J and DBA/2J mice: context discrimination
and the effects of retention interval. Behav Neurosci 116:947-957,
2002.
Talbot, C. J., Radcliffe, R. A., Fullerton, J., Hitzemann, R, Wehner,
J. M., and Flint, J. Fine scale mapping of a genetic locus for conditioned
fear. Mamm Genome 14:223-230, 2003.
Bernert, H., Sekikawa, K., Radcliffe, R. A., Iraqi, F., You, M., and
Malkinson, A. M Tnfa and Il-10 deficiencies have contrasting effects
on lung tumor susceptibility: Gender-dependent modulation of IL-10
haploinsufficiency. Mol Carcinog 38:117-123, 2003.
Radcliffe, R. A., Hoffmann,
S. E., Deng, X-S., Asperi, W., Fay, T., Bludeau, P., Erwin, V. G.,
and Deitrich, R. A. Behavioral characterization of Alcohol-tolerant
and Alcohol-nontolerant rat lines and an F2 generation. Behav Genet
Submitted, 2003.
Radcliffe, R. A., Bowers, B. J., Smith, A. M., and Wehner, J. M. Transcriptional
Profiling of the Cerebellum from PKCg Null Mutant Mice. J Neurochem
Submitted, 2003.
Review Articles
Wehner, J. M., Radcliffe, R. A., and Bowers, B. J. Quantitative genetics
and mouse behavior. Ann Rev Neurosci 24: 845-867, 2001.
Book Chapters
Deitrich, R. A., Radcliffe, R. A. and Erwin, V. G. (1996) Pharmacological
effects in the development of tolerance and physical dependence. In
The Pharmacology of Alcohol and Alcohol Dependence, Begleiter, H.
and Kissin, B., eds. New York: Oxford University Press, chapter 11,
pp. 431-476.
Wehner, J. M. and Radcliffe, R. A. (2001) Cued and Contextual Fear
Conditioning in Mice. In Current Protocols in Neuroscience, Crawley,
J., ed. New York: J. Wiley, chapter 8.
Wehner, J. M. and Radcliffe, R. A. (2003) Cued and Contextual Fear
Conditioning in Mice. (updated version) In Current Protocols in Neuroscience,
Crawley, J., ed. New York: J. Wiley, chapter 8.
Abstracts/Presentations
Erwin, V. G., Jones, B. C. and Radcliffe, R. A. (1990) Calcium-dependent
stimulation of phosphoinositide hydrolysis by neurotensin in brain
slices from long-sleep and short-sleep mice. Alcohol Clin Exp Res
14: 287.
Erwin, V. G., Iozzo, T. M., Campbell, A. D. and Radcliffe, R. (1991)
Characterization of genotype-dependent acquisition of chronic tolerance
and/or sensitization to ethanol-induced locomotor activation. Alcohol
Clin Exp Res 15: 331.
Erwin, V. G., Jones, B. C. and Radcliffe, R. A. (1991) Genetic correlations
among neurotensin levels and receptors and ethanol?related behaviors
in LSXSS recombinant inbred strains of mice. Alcohol Clin Exp Res
15: 322.
Jones, B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. (1991)
Pharmacogenetic analysis of cocaine in mice: Behavior and neurochemistry.
FASEB J 5: A1561.
Jones, B. C., Radcliffe, R. A., Campbell, A. D. and Erwin, V. G. (1991)
Low-dose ethanol effects: Correlated responses in recombinant inbred
mice. Alcohol Clin Exp Res 15: 319.
Radcliffe, R. A. and Erwin, V. G. (1991) Ethanol enhances neurotensin-induced
stimulation of inositol phospholipid metabolism. Society for Neuroscience
Abstracts 17: 422.
Radcliffe, R. A. and Erwin, V. G. (1993) Internalization of neurotensin
receptor-ligand complex in microsacs isolated from murine brain. Society
for Neuroscience Abstracts 19: 298.15.
Radcliffe, R. A. and Erwin, V. G. (1994) Neurotensin reverses locomotor
inhibition produced by microinjections of GBR-12909 into the medial
prefrontal cortex. Society for Neuroscience Abstracts 20: 553.11.
Erwin, V. G., Jones, B. C., and Radcliffe, R. A. (1994) Neurotensin
receptor densities correlate with ethanol induced locomotor activation
in LS, SS, and LSXSS RI strains of mice. Alcohol Clin Exp Res 14:
480.
Radcliffe, R. A. and Erwin, V. G. (1995) Stimulation of dopamine receptors
in the medial prefrontal cortex mediates inhibition of spontaneous
locomotor activity. Society for Neuroscience Abstracts 21: 662.18.
Radcliffe, R. A., Walter, N. A. R., Jones, B. C., Sikela, J. M., and
Erwin, V. G. (1997) QTL and the candidate gene approach: A cautionary
tale. Alcohol Clin Exp Res 21: 93.
Radcliffe, R. A. and Wehner, J. M. (1997) Temporal analyses of contextual
fear conditioning: Further characterization of differences between
C57BL/6 and DBA/2J mice. Society for Neuroscience Abstracts 23: 822.1.
Owen, E. H., Radcliffe, R. A., Rosmann, S. T., Christensen, S. C.,
and Wehner, J. M. (1997) Mapping of genes regulating contextual fear
conditioning in mice. Society for Neuroscience Abstracts 23: 822.4.
Radcliffe, R. A., Erwin, V. G., and Wehner, J. M. (1998) Genetic correlation
between fear conditioning and acute functional tolerance to alcohol.
Alcohol Clin Exp Res 22: 306.
Radcliffe, R. A. and Wehner, J. M. (1999) Gene-environment interactions
influence differences in acute ethanol tolerance in B6 and D2 mice.
Alcohol Clin Exp Res, 23: 330.
Erwin, V. G., Gehle, V. M., Davidson, K. L., and Radcliffe, R. A.
(2000) Correlations and common quantitative trait loci between neurotensin
receptor density and hypnotic sensitivity to ethanol. Alcohol Clin
Exp Res 24: 535.
Malkinson, A. M., Radcliffe, R. A., Bauer A., and Dwyer-Nield, L.
D. (2001) QTLs that regulate susceptibility to the chronic pulmonary
inflammation and lung tumor promotion induced by butylated hydroxytoluene
(BHT). American Association for Cancer Research Special Oncogenomics
Conference.
Hoffmann, S. E., Radcliffe, R. A., Deng, X-S., Fay, T., Salaz, D.,
Bludeau, P., and Deitrich, R. A. (2002) The re-establishment, characterization
and inbreeding of Alcohol-Tolerant and Alcohol-Nontolerant Rat lines.
Alcohol Clin Exp Res 26:575.
Radcliffe, R. A., Hoffmann, S. E., Laster, E. W., Deng, X-S., Bludeau,
P., Erwin, V. G., and Deitrich, R. A. (2002) QTL mapping for acute
tolerance and hypnotic sensitivity to ethanol in an F2 derived from
inbred high and low alcohol sensitivity rats. Alcohol Clin Exp Res
26:576.
Radcliffe, R. A., Hoffmann, S. E., Deng, X-S, Bludeau, P., Fay, T.,
Asperi, W., Erwin, V. G., and Deitrich, R. A. (2003) Inbreeding of
Alcohol-tolerant (AT) and Alcohol-nonteolerant (ANT) rat lines and
characterization of an F2 population. Alcohol Clin Exp Res
Radcliffe, R. A., Miyamoto, J., Wehner, J. M. (2003) Fine Mapping
of a Chromosome 1 QTL for Fear Conditioning Using the Congenic Strategy
Reveals Multiple QTL. QTL to Gene: New strategies & recent progress
for alcohol-related behaviors.
Other Publications
Radcliffe, R. A. DOPS retreat
celebrates research diversity, success stories. School of Pharmacy
News Fall 2003