The molecular, genetic and physiological basis of nicotine addiction using mouse genetic models to study addiction-related phenotypes including conditioned place preference, self administration and oral self-selection.
Selected Publications:
1. Tammimäki, A., Chistyakov, V., Patkina, N., Skippari, J., Ahtee, L., Zvartau, E., Männistö, P.T. (2008) Effect of forced chronic oral nicotine exposure on intravenous self-administration and rewarding properties of acute nicotine. European Journal of Pharmacology, 591:164-170.
| pubmed abstract |
2. Tammimäki, A., Forsberg, M. M., Karayiorgou, M., Gogos, J. A., Männistö, P. T. (2008)
Increase in free choice oral ethanol self-administration in male mice with Comt gene disruption. Basic & Clinical Pharmacology & Toxicology, 103:297-304.
PMID: 17100780 | pubmed abstract |
3. Tammimäki, A., Pietilä, K., Raattamaa, H., Ahtee, L. (2006) Effect of quinpirole on striatal dopamine release and locomotor activity in nicotine-treated mice. European Journal of Pharmacology 531:118-125.
PMID: 17201549 | pubmed abstract |