Identify (polymorphic) loci/genes in mice that confer differential ethanol preference, ethanol sensitivity and anesthetic sensitivity. + New: Identification of Gerontogenes in the Mouse

Current Projects

• "Quantitative Trait loci (QTL) Mapping of Genes Associated with Ethanol Choice" : This project is to map genes that are associated with choice versus avoidance for ethanol consumption.

• "Mapping of Genes Predisposing to Alcohol Sensitivity" : This project is to map genes that are associated with differential sensitivity  to alcohol (length of alcohol induced sleep time) using QTL mapping.

• "QTLs Underlying Molecular Action of General Anesthesia" : This project aims to identify genetic differences that underlie QTL that have been associated with general anesthetic sensitivity  in mice, focusing on a 250 Kb region containing a major gene involved in the action of propofol.

• New: Identification of Gerontogenes in the Mouse.

Current Grants

National Institute on Alcohol Abuse and Alcoholism: "Mapping of Genes Predisposing to Alcohol Sensitivity," (1992 - 2008)

Ellison Medical Foundation, (2002 - 2006)

National Institute on Alcohol Abuse and Alcoholism: " High Efficiency Mapping of Alcohol Sensitivity Genes," (2000 - 2004)

National Institute on Alcohol Abuse and Alcoholism: "Molecular Mapping of Quantitative Loci for Voluntary Ethanol Preference," (1999 - 2004)

National Institute on Alcohol Abuse and Alcoholism: "Identifying Genes Predisposing to Alcoholism," Research Scientist Development Award (1994 - 2004)

Mice

Database: SDP from LSxSS RI strains

Strain distribution patterns (SDPs) of 118 SSLP markers and three pigmentation genes that have been characterized in 27 strains from the LSXSS RI series.  This coarse map provides a resource for linkage studies of phenotypes that are heritable in the LSXSS recombinant inbred (RI) series.

Database: Recombinant Inbred (RI) Strain Distribution Pattern

Strain distribution pattern (SDP) of 330 SSLP markers has been characterized in 77 LXS RI strains. This map provides a resource for linkage studies of phenotypes that are heritable in the LXS recombinant inbred (RI) strains.