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J Investig Dermatol Symp Proc 1998 Aug;3(1):6-10

A relationship between thermotolerance and longevity in Caenorhabditis elegans.

Walker GA, Walker DW, Lithgow GJ

The School of Biological Sciences, The University of Manchester, UK.

Studies of aging in the nematode Caenorhabditis elegans have revealed a relationship between stress resistance and the rate of aging: Mutations which extend mean and maximum life-span also confer resistance to thermal stress. We review the molecular genetics of aging in C. elegans and introduce methods for obtaining novel mutants which display altered aging rates. We present the use of the "surrogate" phenotype of thermotolerance to develop a selection for novel mutations which slow aging.