QTDT - Quantitative TDT 2.2.1 (c) 1998-2001 Goncalo Abecasis (goncalo@well.ox.ac.uk) This program implements tests described by Abecasis et al, Am J Hum Genet 66:279-292 (2000) Abecasis et al, Eur J Hum Genet 8:545-551 (2000) and others The following parameters are in effect: QTDT Data File : keavney.dat (-dname) QTDT Pedigree File : keavney.ped (-pname) QTDT IBD Status File : merlin.ibd (-iname) Missing Value Code : -99.999 (-xname) Covariates : USER SPECIFIED (-c{p|s|u|-|}) Association Model : NONE (-a[a|d|f|m|o|p|r|t|w|-]) Full Model Variances : NON SHARED (-v{e|c|g|n|t|a|d|-|}) & POLYGENIC & ADDITIVE Null Model Variances : NON SHARED (-w{e|c|g|n|t|a|d|-|}) & POLYGENIC Parent of Origin Effects : NONE (-o[f|t|m|p|-]) Monte-Carlo Permutations : 0 (-m9999) Numeric Minimizer : NELDER AND MEAD (-n[n|p]) Transmission Scoring : FULL PEDIGREE (-t[n|p]) Additional Options --dominance, --snp, --multi-allelic, --references, --exclude-founder-phenotypes Online documentation http://www.well.ox.ac.uk/asthma/QTDT Comments, bugs: goncalo@well.ox.ac.uk The following models will be evaluated... NULL MODEL Means = Mu Variances = Ve + Vg FULL MODEL Means = Mu Variances = Ve + Vg + Va Testing trait: Angiotensin ============================================= Testing marker: t-5491c --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.96 33.54 7e-09 (401 probands) Testing marker: a-5466c --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.96 33.54 7e-09 (401 probands) Testing marker: t-3892c --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.96 33.53 7e-09 (401 probands) Testing marker: a-240t --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.97 33.52 7e-09 (401 probands) Testing marker: t-93c --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.97 33.52 7e-09 (401 probands) Testing marker: t-1237c --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.99 33.49 7e-09 (401 probands) Testing marker: g2215a --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.99 33.49 7e-09 (401 probands) Testing marker: i/d --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.99 33.49 7e-09 (401 probands) Testing marker: g2350a --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.99 33.48 7e-09 (401 probands) Testing marker: 4656ct --------------------------------------------- Allele df(0) LnLk(0) df(V) LnLk(V) ChiSq p 1 : 398 540.73 397 523.81 33.84 6e-09 (401 probands)