CURRICULUM VITAE
(last updated 2/28/01)
Richard Adams
Radcliffe
I. GENERAL INFORMATION
Home Address: 1919 Quail Court Home: (303) 665-8551
Louisville,
CO 80027
Office
Address: Department of
Pharmacology Office: (303) 315-8609
University
of Colorado Health Sciences Center Lab: (303) 315-8259
Campus
Box C236 Cell: (303)
570-8852
Denver,
CO 80262
E-mail: richard.radcliffe@colorado.edu
Birthdate: April 10, 1958
Marital
Status: Married
Spouse
Name: Carol Victoria
Radcliffe
Children: Caitlin Elizabeth,
Julianne Sarah
II. EDUCATION
YEAR INSTITUTION DEGREE
1984 Virginia Tech B.
S., Biology
1985-1986 University
of Virginia Teaching
Certificate,
Secondary
School Biology
1991-1996 University of Colorado Ph.
D., Pharmaceutical
Health
Sciences Center Sciences
III. PROFESSIONAL EXPERIENCES
1985-1986
Laboratory
Specialist in the Laboratory of Dr. Yong I. Kim at the University of
Virginia, Charlottesville
1986‑1987 Math and Science Teacher
at Waynesboro High School, Waynesboro, Virginia
1987‑1991 Professional
Research Assistant/Laboratory Manager in the Laboratory of Dr. V.
Gene
Erwin at the University of Colorado, Boulder, Colorado
1991‑1996 Research Assistant in the
Laboratory of Dr. V. Gene Erwin at the University of
Colorado
Health Sciences Center, Denver, Colorado
1996-1999 Research Associate in the
Laboratory of Dr. Jeanne M. Wehner at the Institute for
Behavioral Genetics,
University of Colorado, Boulder, Colorado
1999-present Instructor, Department of
Pharmacology, University of Colorado Health Sciences
Center, Denver, Colorado
IV. WORKSHOPS ATTENDED
V. HONORS, SCHOLARSHIPS, and FELLOWSHIPS
Academic Achievement Research Award, Graduate
School, University of Colorado Health Sciences Center, 1992
Outstanding Presentation Award, Department of
Pharmaceutical Sciences, University of Colorado Health Sciences Center, 1995
Colorado Doctoral Fellowship,
1995
Institute for Behavioral Genetics Postdoctoral
Training Fellowship, 1996-1998
VI. TEACHING ACTIVITY
YEAR COURSE LECTURE HOURS STUDENTS
2000 Pharmacology &
Pharmacotherapeutics II 12 80
(School of
Pharmacy, UCHSC)
2000 Pathophysiology
2 80
(School of
Pharmacy, UCHSC)
(School of
Medicine, UCHSC)
2000 QTL Mapping in Model
Organisms
3 10
(Institute for
Behavioral Genetics)
VII. PROFESSIONAL ACTIVITY
A. Membership in Professional
Organizations
Behavior Genetics Association
Research Society on Alcoholism
Society for Neuroscience
B. Editorial Activities
Editorial Board:
Behavior Genetics
Ad Hoc Reviews:
Pharmacology, Biochemistry, and Behavior
Alcoholism: Clinical and Experimental Research
Journal of Studies on Alcohol
Neuropshychopharmacology
Journal of Pharmacology and Experimental Therapeutics
VIII. SPEAKING ENGAGEMENTS
YEAR ORGANIZATION TITLE
1997 Behavior Genetics
Association Mapping QTLs
for Fear Conditioning
Toronto, Canada
1999 Colorado Alcohol
Research Center Genetic Studies
on the Relationship Between
University of Colorado Health Learning
and Acute Ethanol Tolerance
Sciences Center, Denver,
Colorado
City, California
2000 National Institute on Alcohol Abuse Mapping of Common QTLs for Ethanol
Sensitivity
and Alcoholism QTL Mapping and Neurotensin
Receptors
Workshop, Rockville, Maryland
IX. GRANTS/RESEARCH
ACTIVITY
RO1
Research Grant: “Gene Expression
Analysis of Drug-induced Alterations in Sensitivity to Alcohol” National Institute on Alcohol Abuse and
Alcoholism. Pending. $675,000.
3/1/01-2/30/04
X. PUBLICATIONS
A. Refereed
Journals
Erwin,
V. G., Jones, B. C. and Radcliffe, R. Further characterization of LS X SS recombinant
inbred strains of mice: Activating and hypothermic effects of ethanol. Alcoholism: Clinical and
Experimental Research, 14:200-204,
1990.
Erwin,
V. G., Jones, B. C. and Radcliffe, R. Low doses of ethanol reduce neurotensin
levels in discrete brain regions from LS/lbg and SS/lbg mice. Alcoholism:
Clinical and Experimental Research, 14:42-47,
1990.
Jones,
B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. Cocaine actions,
brain levels and receptors in selected lines of mice. Pharmacology
Biochemistry and Behavior, 40:941‑948,
1991.
Erwin,
V. G., Radcliffe, R. and Jones, B. C. Chronic ethanol consumption produces
genotype‑dependent tolerance to ethanol in LS/lbg and SS/lbg mice. Pharmacology Biochemistry and
Behavior, 41:275‑281,
1992.
Erwin, V. G., Campbell, A. D.
and Radcliffe, R. A. Effects of chronic ethanol administration on
neurotensinergic processes: Correlations with tolerance in LS and SS mice. Annals of the New York
Academy of Sciences, 654:441‑443, 1992.
Jones, B. C., Campbell, A.
D., Radcliffe, R. A. and Erwin, V. G. Psychomotor stimulant effect of cocaine
is affected by genetic makeup and experimental history. Annals of the New
York Academy of Sciences, 654:456-458,
1992.
Jones, B. C., Reed, C. L.,
Radcliffe, R. A. and Erwin, V. G. Pharmacogenetics of cocaine: I. Locomotor
activity and self‑selection in C57BL and DBA mice. Pharmacogenetics, 3:182-188,
1993.
Erwin, V. G., Radcliffe, R.
A., Hinkle, B. and Jones, B. C. Genetic‑based differences in neurotensin
levels and receptors in brains of LSXSS mice. Peptides, 14:821-828,
1993.
Erwin, V. G. and Radcliffe,
R. A. Characterization of neurotensin‑stimulated phosphatidylinositol
hydrolysis in brain regions of LS and SS mice. Brain Research,
629:59-66, 1994.
Radcliffe, R. A. and Erwin,
V. G. Alterations in locomotor activity following microinjections of GBR-12909,
selective dopamine antagonists, or neurotensin into the medial prefrontal
cortex. Journal of Pharmacology and
Experimental Therapeutics, 277:1467-1476, 1996.
Erwin, V. G., Radcliffe, R.
A., Gehle, V. M., and Jones, B. C. Common quantitative trait loci for
alcohol-related behaviors and central nervous system neurotensin measures:
Locomotor activation. Journal of
Pharmacology and Experimental Therapeutics, 280:919-926, 1997.
Wehner, J. M., Radcliffe, R.
A., Rosman, S. T., Christensen, S. C., Rasmussen, D. L., Fulker, D. F., and
Wiles, M. Quantitative trait loci analysis of contextual fear conditioning in
C57BL/6J X DBA/2J F2 mice. Nature Genetics, 17:331-334, 1997.
Radcliffe, R. A., Jones, B.
C., and Erwin, V. G. Mapping of provisional quantitative trait loci influencing
temporal variation in locomotor activity in the LSXSS recombinant inbred
strains. Behavior Genetics, 28:39-47,
1998.
Radcliffe, R. A., Walter, N.
A. R., Sikela, J. M., and Erwin, V. G. Discovery of a new Pomc1 allele in the LSXSS recombinant inbred strains: Relationship
to locomotor behavior. Behavior Genetics, 28:49-55, 1998.
Radcliffe, R. A. and Erwin,
V. G. Genetic relationship between central b-endorphin and
novelty-induced locomotor activity. Pharmacology Biochemistry and Behavior,
60:709-718, 1998.
Radcliffe,
R. A., Erwin, V. G., and Wehner, J. M. Acute functional tolerance to ethanol
and fear conditioning are genetically correlated in mice. Alcoholism:
Clinical and Experimental Research, 22:1673-1679,
1998.
Turri,
M. G., Talbot, C. J., Radcliffe, R. A., Wehner, J. M., and Flint, J.
High-resolution mapping of quantitative trait loci for emotionality in selected
strains of mice. Mammalian Genome, 10:1098-1101,1999.
Radcliffe,
R. A., Lowe, M. V., and Wehner, J. M. Confirmation of contextual fear
conditioning QTLs by short-term selection. Behavior Genetics. 30:183-191, 2000.
Wick, M. J., Radcliffe, R. A., Bowers, B. J.,
Mascia, M. P., Lüscher, B., Harris, R. A., and Wehner, J. M.
Behavioral changes produced by transgenic overexpression of γ2L and
γ2S subunits of the GABAA receptor. European Journal of
Neuroscience 12:2634-2638, 2000.
Radcliffe, R. A., Bohl, M. L., Lowe, M. V.,
Cycowski, C. S., and Wehner, J. M. Mapping of quantitative trait loci for
hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2
mouse strains. Alcoholism: Clinical and Experimental Research 24: 1335-1342, 2000.
Wehner,
J. M., Radcliffe, R. A., and Bowers, B. J. Quantitative genetics and mouse
behavior. Annual Review of Neuroscience. In press, 2001.
Vissel,
B., Royle, G. A., Christie, B. R., Schiffer, H.H., Ghetti, A., Tritto, T.,
Perez-Otano, I., Radcliffe, R. A., Seamens, J., Sejnowski, T., Wehner, J. M.,
Collins, A. C., O’Gorman, S., and Heinemann, S. F. The role of RNA editing of
kainate receptors in synaptic plasticity and seizures. Neuron. In press,
2001.
Erwin,
V. G., Gehle, V. M., Davidson, K. L., and Radcliffe, R. A. Correlations and
common quantitative trait loci between neurotensin receptor density and
hypnotic sensitivity to ethanol. Alcoholism: Clinical and Experimental
Research. Submitted, 2001.
Radcliffe,
R. A., Tritto, T., Marks, M. J., Stitzel, J.,and Collins, A. C. Mapping of
provisional quantitative trait loci for nicotine-induced seizures in the LS X
SS recombinant inbred strains. In preparation, 2001.
Malkinson,
A. M., Radcliffe, R. A., and Bauer, A. K. Quantitative Trait Locus (QTL)
Mapping of Susceptibilities to
Butylated Hydroxytoluene (BHT)-induced Lung Tumor Promotion and
Pulmonary Inflammation in CXB Mice. In preparation, 2001.
B. Book
Chapters
Deitrich, R. A., Radcliffe, R. A. and Erwin, V. G.
Pharmacological effects in the development of tolerance and physical
dependence. In The Pharmacology of Alcohol and Alcohol Dependence,
Begleiter, H. and Kissin, B., eds. New York: Oxford University Press, chapter
11, pp. 431-476, 1996.
Wehner,
J. M. and Radcliffe, R. A. Cued and Contextual Fear Conditioning in Mice. In Current
Protocols in Neuroscience. In press, 2000.
C. Abstracts
Erwin, V. G., Jones, B. C. and Radcliffe, R. A.
Calcium‑dependent stimulation of phosphoinositide hydrolysis by
neurotensin in brain slices from long‑sleep and short‑sleep mice. Alcoholism:
Clinical and Experimental Research 14:
287, 1990.
Erwin,
V. G., Iozzo, T. M., Campbell, A. D. and Radcliffe, R. Characterization of
genotype‑dependent acquisition of chronic tolerance and/or sensitization
to ethanol‑induced locomotor activation. Alcoholism: Clinical and
Experimental Research 15: 331,
1991.
Erwin,
V. G., Jones, B. C. and Radcliffe, R. A. Genetic correlations among neurotensin
levels and receptors and ethanol‑related behaviors in LSXSS recombinant
inbred strains of mice. Alcoholism:
Clinical and Experimental Research 15:
322, 1991.
Jones,
B. C., Campbell, A. D., Radcliffe, R. A. and Erwin, V. G. Pharmacogenetic
analysis of cocaine in mice: Behavior and neurochemistry. The FASEB Journal
5: A1561, 1991.
Jones,
B. C., Radcliffe, R. A., Campbell, A. D. and Erwin, V. G. Low‑dose
ethanol effects: Correlated responses in recombinant inbred mice. Alcoholism:
Clinical and Experimental Research 15:
319, 1991.
Radcliffe,
R. A. and Erwin, V. G. Ethanol enhances neurotensin‑induced stimulation
of inositol phospholipid metabolism. Society for Neuroscience Abstracts 17: 422, 1991.
Radcliffe,
R. A. and Erwin, V. G. Internalization
of neurotensin receptor-ligand complex in microsacs isolated from murine brain.
Society for Neuroscience Abstracts 19:
298.15, 1993.
Radcliffe,
R. A. and Erwin, V. G. Neurotensin
reverses locomotor inhibition produced by microinjections of GBR-12909 into the
medial prefrontal cortex. Society for Neuroscience Abstracts 20: 553.11, 1994.
Erwin,
V. G., Jones, B. C., and Radcliffe, R. A. Neurotensin receptor densities
correlate with ethanol induced locomotor activation in LS, SS, and LSXSS RI
strains of mice. Alcoholism: Clinical and Experimental Research 14: 480, 1994.
Radcliffe,
R. A. and Erwin, V. G. Stimulation of
dopamine receptors in the medial prefrontal cortex mediates inhibition of
spontaneous locomotor activity. Society for Neuroscience Abstracts 21: 662.18, 1995.
Radcliffe,
R. A., Walter, N. A. R., Jones, B. C., Sikela, J. M., and Erwin, V. G. QTL and
the candidate gene approach: A cautionary tale. Alcoholism: Clinical and Experimental Research 21: 93, 1997.
Radcliffe,
R. A. and Wehner, J. M. Temporal analyses of contextual fear conditioning:
Further characterization of differences between C57BL/6 and DBA/2J mice. Society
for Neuroscience Abstracts 23:
822.1, 1997.
Owen,
E. H., Radcliffe, R. A., Rosmann, S. T., Christensen, S. C., and Wehner, J. M.
Mapping of genes regulating contextual fear conditioning in mice. Society
for Neuroscience Abstracts 23: 822.4, 1997.
Radcliffe,
R. A., Erwin, V. G., and Wehner, J. M. Genetic correlation between fear
conditioning and acute functional tolerance to alcohol. Alcoholism: Clinical
and Experimental Research 22:
306, 1998.
Radcliffe,
R. A. and Wehner, J. M. Gene-environment interactions influence differences in
acute ethanol tolerance in B6 and D2 mice. Alcoholism: Clinical and
Experimental Research, 23: 330,
1999.
Erwin,
V. G., Gehle, V. M., Davidson, K. L., and Radcliffe, R. A. Correlations and
common quantitative trait loci between neurotensin receptor density and
hypnotic sensitivity to ethanol. Alcoholism: Clinical and Experimental
Research 24: 535, 2000.
Malkinson, A. M., Radcliffe, R. A.,
Bauer A., and Dwyer-Nield, L. D. QTLs that regulate susceptibility to the
chronic pulmonary inflammation and lung tumor promotion induced by butylated
hydroxytoluene (BHT). American Association for Cancer Research Special
Oncogenomics Conference (submitted) 2001.
REFERENCES
V. Gene Erwin, Ph. D.
School
of Pharmacy
University
of Colorado Health Sciences Center
4200
East Ninth Avenue
Campus
Box 238
Denver,
CO 80262
303-315-4606
Jeanne M Wehner, Ph. D.
Institute
for Behavioral Genetics
University
of Colorado
Campus
Box 447
Boulder,
CO 80303
303-492-5663
Thomas E. Johnson, Ph. D.
Institute
for Behavioral Genetics
University
of Colorado
Campus
Box 447
Boulder,
CO 80303
303-492-0279
Richard A. Deitrich, Ph. D.
School
of Medicine
University
of Colorado Health Sciences Center
4200
East Ninth Avenue
Campus
Box 236
Denver,
CO 80262
303-315-7076
Alvin M. Malkinson, Ph. D.
School
of Pharmacy
University
of Colorado Health Sciences Center
4200
East Ninth Avenue
Campus
Box 238
Denver,
CO 80262
303-315-4579
Dennis R. Petersen, Ph. D.
School
of Pharmacy
University
of Colorado Health Sciences Center
4200
East Ninth Avenue
Campus
Box 238
Denver,
CO 80262
303-315-6159
Byron C. Jones, Ph. D.
College
of Health and Human Development
Department
of Biobehavioral Health
Pennsylvania
State University
315
East Health and Human Development Building
University
Park, PA 16802
814-863-0167
Allan C. Collins, Ph. D.
Institute
for Behavioral Genetics
University
of Colorado
Campus
Box 447
Boulder,
CO 80303
303-492-8752
James M. Sikela, Ph. D.
School
of Medicine
University
of Colorado Health Sciences Center
4200
East Ninth Avenue
Campus
Box 236
Denver,
CO 80262
303-315-8637