PSYCH
5112: CONCEPTS IN BEHAVIORAL GENETICS
Spring 2004 (Class Meetings: Wednesdays, 9:00a - 11:30a)
Instructor:
Dr. Michael Stallings
Phone: IBG (MWF): 2-2826 Muenzinger (TTH): 5-3668
Email: Michael.Stallings@Colorado.Edu
Syllabus: click here, get printable
version here.
Course
Objectives
The focus
of this course will be on the development of models for mapping quantitative
trait loci (QTL) in experimental populations and in human family studies.
The course will be introductory, but previous completion of quantitative
genetics and biometrical methods is recommended. There will be an emphasis
on the derivation of model expectations and their application to empirical
data using available software.
Course
Materials
The primary
textbook for the course will be Statistics in Human Genetics (1998)
by Pak Sham. However, there will be also be weekly supplemental readings
assigned.
Additional
supplemental texts include:
Assessment
and Evaluation
Course objectives
will be evaluated through approximately weekly homework exercises and
a written project. The written project will be the write up of a results
section of an analysis utilizing methods covered in the course. You
may use your own data (ideally), or you can see me for sample data.
The results write-up will be limited to 5 pages (double-spaced), with
a 1-page introduction briefly summarizing the motivation for the investigation.
You will also be limited to a maximum of 5 figures and 5 tables in summarizing
your findings.
Syllabus
DATE |
TOPIC |
01/14 |
Course Introduction and
Introduction to Biometrical Genetics |
01/21 |
Introduction to Biometrical
Genetics II |
01/28 |
QTL Mapping With F2s |
02/04 |
QTL Mapping With F2s
and RIs |
02/11 |
Introduction to Parametric
Linkage Analysis in Extended Pedigrees |
02/18 |
Parametric Linkage Analysis
- Part II |
02/25 |
Genotyping and Error Checking
|
03/03 |
METHODOLOGY WORKSHOP:
No Class |
03/10 |
IBD and Genetic Covariance |
03/17 |
Nonparametric Linkage
Methods |
03/24 |
Spring Break!
No Classes |
03/31 |
QTL Mapping Using Mx |
04/07 |
QTL Mapping in Selected
Samples |
04/14 |
Association Studies I |
04/21 |
Association Studies II |
04/28 |
Combined Linkage and
Association Analysis |