American Journal of Human Genetics 1994; 55:825-833
The Power of Interval Mapping of Quantitative Trait Loci, Using Selected Sib Pairs.
Cardon, L. R., & Fulker, D. W.
The interval-mapping procedure for analysis of quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.
Supported by a previous NIDA grant.