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Genetic Epidemiology 2000; 19:S22. Variance components QTL linkage analysis of selected and non-normal samples: conditioning on trait values.Sham, P.C., Zhao, J.H., Cherny, S., & Hewitt, J.K.Standard variance-components QTL linkage analysis can produce an elevated rate of type 1 errors when applied to selected samples and non-normal data. Here we describe an adjustment that leads to a test that is valid in these samples. |
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