American Journal of Human Genetics, 2002; 114:144-149.
Dopamine transporter polymorphism associated with externalizing behavior
problems in children.
Young, S.E., Smolen, A., Corley, R.P., Krauter, K., DeFries, J.C., Crowley,
T.J., & Hewitt, J.K.
We examined the relationship between parent reported externalizing behavior
assessed at ages 4, 7, and 9 years and the VNTR polymorphism of the 3' untranslated
region of SLC6A3 (DAT1) in a community sample of 790 children ascertained
as part of our longitudinal twin and adoption studies. We have demonstrated
that the 9-repeat variant of the DAT1 is a significant risk allele for externalizing
behavior at ages 4 and 7 years.