D. Breed - Professor, Department
of Ecology and Environmental Biology. Professor Breed's research
emphasis is the genetics of social recognition systems in animals.
His current interests include behavioral and genetic studies of
the recognition cues used by honeybees to discriminate nestmates
from non-nestmates. He is presently engaged in investigating the
role of cuticular compounds in recognition, and the patterns of
inheritance of chemical cuticular signatures.
Carey - Associate Professor, Department of Psychology. Dr.
Carey's research interests are in the areas of genetics and human
psychopathology. Within these areas, his work concentrates on
the anxiety disorders and on the development of externalizing
behavior (antisocial tendencies, drug abuse, and alcohol abuse)
during adolescence. A second major interest is the use of quantitative
models to represent mechanisms of assortative mating, development,
cultural transmission, and sibling interactions.
- Professor of Psychology and Pharmacology, Department
of Psychology. Professor Collins is a biochemical pharmacologist
whose primary research specialization is neurochemistry. His current
research interests include neurochemical correlates of nicotine
use, tolerance development, and withdrawal; neurochemical bases
of alcohol tolerance; biochemical bases of behavior; and use of
genetics as a tool to determine the mechanism of action of drugs.
- Professor, Department of Psychiatry; Director, Division
of Substance Dependence, University of Colorado School of Medicine.
Thomas Crowley currently heads a number of studies that focus
on genetic and environmental influences on the development of
behavior problems and substance abuse issues among adolescents.
Additional interests include the feasibility of executive cognitive
functioning tasks in adolescents with serious substance and conduct
problems compared to community controls, as well as the feasibility
of conducting fMRI research in troubled adolescents and a control
group of general population adolescents.
- Professor, Department of Psychology. Professor
DeFries' primary field of specialization is quantitative behavioral
genetics. His current research interests include twin and adoption
studies of human cognitive abilities; the genetics of learning
disabilities; and the use of DNA markers to map quantitative trait
loci (QTLs) that influence behavioral characters.
- Professor, Department of Pharmacology, University
of Colorado Health Sciences Center, Denver. Professor Deitrich
is a pharmacologist whose current research concerns the molecular
basis of the actions of alcohol. His research uses genetically
selected lines of mice and rats to discover mechanisms of central
nervous system depression, tolerance and dependence. These data
are used to identify specific genes responsible for these actions
in animals, and eventually to identify similar genes in humans
at risk for development of alcoholism.
Ehringer - Assistant Professor, Department of Integrative Physiology.
Dr. Ehringer is a molecular geneticist who utilizes the genomics
and bioinformatics resources to study behavior genetics. Her current
research involves the study of candidate genes that may be underlie
genetic mechanisms that contribute to alcohol, tobacco, and substance
K. Hewitt - Director of IBG and Professor of Psychology, CU
Boulder; Professor of Psychiatry (Attendant Rank), School of Medicine,
UCHSC; President of the Behavior
Genetics Association, 2000-01; Executive Editor, Behavior
Genetics. Professor Hewitt uses cross-sectional and longitudinal
studies of twins and families to study behavioral development,
and genetic and environmental influences on behavior, personality,
and health. His recent research has focused on the development
of behavior problems in childhood and adolescence, vulnerability
to drug use, abuse, and dependence, genetics and health, and linkage
and association studies of behavioral traits.
- Professor of Behavioral Genetics, Department
of Integrative Physiology. Dr. Johnson received the Kleemeier
Award (the premier award in aging research) for his discovery
of the first gerontogene, age-1, which doubles the life span and
opened up a new area of scientific research. He is also cloning
quantitative trait loci conferring sensitivity to alcohol in mice.
His lab uses multiple techniques: behavioral, biochemical molecular,
pharmacological, quantitative and genetic, to analyze both aging
and the action of genes leading to addiction. For more information
examine his URL http://ibgwww.colorado.edu/tj-lab
| Matthew C Keller
- Assistant Professor of Psychology, Department of Psychology. Dr Keller's current research focus is in testing evolutionary hypotheses using human genetic data, and modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
S. Krauter - Professor, Department of Molecular, Cellular and
Developmental Biology. Dr. Krauter's research focuses on two aspects
of human genome research. The first is in the area of comparative
genome analysis. The second is the use of genetic analysis to identify
genes involved in complex traits such as behavioral abnormalities.
- Professor, Department of Ecology and Environmental
Biology. Professor Lynch's research interests are the genetic
basis of evolutionary adaptation and brain mechanisms underlying
adaptive behaviors. Her current research uses a model system which
has been the study of cold adaptation in mice, with emphasis on
nest-building. This involves the use of replicated genetic lines
of mice that have been selectively bred for over sixty generations
for differences in nest-building. These lines also differ in genetically
correlated traits, such as body weight and litter size, as well
as circadian rhythms and brain (hypothalamus) neurochemistry and
neuroanatomy. These lines facilitate studies of both constraints
on adaptive evolution and the path from genes to behavior.
- Assistant Professor, Department of Psychology. Dr. McQueen's research is focused on a multi-faceted approach to
the investigation of genetic determinants underlying complex
disease, with a particular interest in psychiatric, behavioral and
neurologic disorders. Recent areas of research include the
development and application of statistical and epidemiological
methods geared towards genome-wide association in both
family-based and population-based samples.
- Professor, Department of Psychology. Professor
Olson is a developmental psychologist whose primary research is
on the varieties, etiology and remediation of learning disorders.
His research has examined the component processes in reading and
related language skills that are associated with both normal and
subnormal development. Heritability of these component processes
is being evaluated through twin analyses. Current projects are
focused on the use of computer speech feedback in the remediation
of reading disabilities.
F. Pennington - Professor, Department of Psychology, and Director
of the Developmental Cognitive Neuroscience Program, University
of Denver. Professor Pennington is a developmental neuropsychologist
whose research focuses on understanding disorders of cognitive
development. The disorders he studies include developmental dyslexia,
attention deficit hyperactivity disorder, and several mental retardation
syndromes: early treated phenylketonuria, fragile X syndrome,
Down syndrome, and infantile autism. The long-term goal of this
work is to understand how different genetic influences alter brain
development to produce the disti
profiles of cognitive strengths and weaknesses found in each of
- Professor of Pharmacology and Pharmacogenetics,
School of Pharmacy. Professor Petersen's research concerns biochemical
pharmacology and toxicology of alcohols and aldehydes. This research
focuses on enzyme systems in liver, kidney and brain that are
involved in the biotransformation of endogenous and exogenous
aldehydes. Of particular interest is the interaction of acute
or chronic alcohol consumption with these enzymatic pathways.
His recent research efforts have emphasized the use of genetics
in studying the molecular and biochemical mechanisms underlying
the hepatotoxic potential of various drugs and chemicals.
- Assistant Professor of Pharmacology, Department
of Pharmaceutical Sciences. Dr. Radcliffe's research focuses on
the genetic and molecular basis of drug and alcohol abuse. Current
projects include gene expression microarray analyses of CNS systems
involved in behavioral responses to methamphetamine and alcohol,
QTL mapping of alcohol-related traits, mutagenesis approaches
applied to the study of acute alcohol tolerance, and studies of
the non-linear dynamics of the fear conditioning response.
- Assistant Professor of Clinical Psychology. Dr. Rhee's
primary research interests are the etiology and development of
childhood disruptive disorders, the etiology and development of
substance use disorders, the causes of comorbidity between psychiatric
disorders and substance use disorders, and the development of
methods discriminating correct models for causes of comorbidity.
- Professor, Department of Pharmacology and Human Medical
Genetics Program, University of Colorado Health Sciences Center,
Denver. Dr. Sikela is a genome scientist and has been a key pioneer
in the development of EST technology and large-scale human gene
mapping. His laboratory was part of the international gene-mapping
consortium that determined the chromosomal location for the majority
of human genes. He contributed to the discovery of the PSN2 gene
that causes Alzheimer's disease. Currently his research involves
applying genomics approaches to the discovery of genes involved
in alcoholism and drug abuse. His laboratory is also involved
in the identification of genes important to hominoid evolution,
including those that are specific to the human lineage.
Smolen - Senior Research Associate, IBG. Dr. Smolen is a pharmacologist
whose primary interests are in the areas of neurochemistry and
pharmacogenetics. His current research activities include the
assessment of the contribution of specific candidate genes to
complex behaviors such as substance abuse and Attention Deficit
N. Smolen - Research Associate, Assistant Director, IBG. Dr.
Smolen's research interests are in the areas of pharmacogenetics
and neuropharmacology. Her current projects use genetically inbred
and selected lines of mice in studies of biochemical and neurochemical
mechanisms that underlie the development of drug tolerance and
dependence, the role of the adenosine neuromodulatory system in
the mediation of the effects of acute and chronic alcohol administration,
and drug metabolism in young and aging mice.
- Associate Professor, Department of Psychology.
Dr. Stallings' research interests include quantitative genetics,
substance abuse, and personality. His current research utilizes
biometrical modeling and quantitative trait loci (QTL) methodology
to understand genetic and environmental influences on the development
of substance use disorders and comorbid psychopathology.
- Assistant Professor, Department of Integrative
Physiology. Dr. Stitzel is a molecular biologist whose primary
interest is the use of genetic strategies to identify the underlying
biological bases for the behavioral and physiological actions
of drugs of abuse with special emphasis on nicotine. Current projects
include the molecular, biochemical and cellular characterization
of naturally occurring variants of neuronal nicotinic receptors
and quantitative trait loci mapping of a nicotine preference phenotype.
Boris Tabakoff - Professor
and Chairman, Department of Pharmacology, University of Colorado
Health Sciences Center, Denver. Professor Tabakoff's research
concerns physiological, pharmacological, and biochemical correlates
of alcohol and opiate/cannabinoid abuse. Current studies focus
on behavioral genetic factors mediating tolerance development;
the involvement of brain glutamate receptors in addiction; and
the interaction of addictive drugs with adenylyl cyclase signaling
- Professor Emerita, Department of Psychology.
Professor Wehner is a biochemist whose primary research interests
are pharmacogenetics and neurobiology. Current projects include
biochemical and genetic studies of learning and memory, the role
of nicotinic receptors in modulation of learning and the role
of protein kinase C in alcohol's actions.
Willcutt- Assistant Professor of Clinical Psychology, Department
of Psychology. Professor Willcutt's current research focuses on
the causes and consequences of attention deficit hyperactivity disorder,
learning disabilities, and their comorbidity. He uses genetic linkage
and association techniques in studies of families and twins to identify
genes that increase susceptibility to these difficulties.
James R. Wilson
- Professor Emeritus, Department of Psychology. Professor
Wilson's primary field of specialization is behavioral biology.
His research interests have included the endocrinological and
genetic bases of maternal behavior, sexual behavior, activity
differences, and learning differences in mice; and genetic studies
of cognitive functions in humans. Recent work involved genetic
selection in mice for alcohol dependence, behavioral genetic
studies of alcohol dosing and cigarette withdrawal in humans,
and studies of neuroelectric treatment for cigarette addiction
and for alleviation of migraine headaches. Professor Wilson
is currently teaching an on-line behavioral genetics course
for the University of Colorado at Denver.