Jeanne M. Wehner Publications

1. Snustad DP, Parson KA, Warner HR, Tutas DJ, Wehner JM, Koerner JF: Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: II. Physiological state of the host nucleotide in infected cells. Journal of Molecular Biology 89: 675-687, l974.

2. Tutas DJ, Wehner JM, Koerner JF: Unfolding of the host genome after infection of Escherichia coli with bacteriophage T4. Journal of Virology 13: 548-550, l974.

3. Wehner JM, Sheppard JR, Malkinson AM: Density-dependent phosphorylation of a specific protein in cultured cells. Nature 266: 842-844, l977.

4. Sheppard JR, Brus D, Wehner JM: Brain reaggregate cultures: Biochemical evidence for myelin membrane synthesis. Journal of Neurobiology 9: 309-315, l978.

5. Wehner JM, Sheppard JR: Protein phosphorylation. In SB Day (ed.), A Companion to the Life Sciences. New York: Van Nostrand Reinhold, 1979. Pp. 388-389.

6. Stafstrom CE, Johnston D, Wehner JM, Sheppard JR: Spontaneous neural activity in fetal brain reaggregate cultures. Neuroscience 5: 1681-1689, 1980.

7. Wehner JM, Malkinson AM, Wiser MF, Sheppard JR: Cyclic AMP-dependent protein kinase enzymes from BALB 3T3 and other 3T3 derived lines. Journal of Cell Physiology 108: 175-184, l981.

8. Wehner JM, Feinman RD, Sheppard JR: Beta-adrenergic response in CNS reaggregate cultures. Developmental Brain Research 3: 207-217, 1982.

9. Bloomer JR, Reuter RJ, Morton KO, Wehner JM: Enzymatic formation of zinc-protoporphyrin by rat liver and its potential effect on hepatic heme metabolism. Gastroenterology 85: 663-668, 1983.

10. Malkinson AM, Beer DS, Wehner JM, Sheppard JR: Elution of the regulatory subunit of cAMP-dependent protein kinase type I isozyme derived from epididymal fat within the type II isozyme chromatographic peak. Biochemical and Biophysical Research Communications 112: 214-220, 1983.

11. Sheppard JR, McSwigan JD, Wehner JM, White JG, Shows TB, Jacobs KH, Schultz G: Adrenergic response in Down Syndrome. In VE Anderson, JW Eaton, JR Sheppard (eds.), Human Genetics and Membrane Biology. New York: Alan R. Liss, 1983. Pp. 307-325.

12. Sheppard JR, Wehner JM, McSwigan JD, Shows TB: Chromosomal assignment of the gene for the human beta-adrenergic receptor. Proceedings of the National Academy of Sciences 80: 233-246, l983.

13. Wehner, JM, Smolen A, Smolen TN, Murphy C: Recovery of acetylcholinesterase activity after acute organophosphate treatment of CNS reaggregate cultures. Fundamental and Applied Toxicology 5: 1104-1109, 1985.

14. Smolen A, Smolen TN, Wehner JM, Collins AC: Genetically determined differences in acute response to diisopropylfluorophosphate. Pharmacology Biochemistry and Behavior 22: 623-630, 1985.

15. Wehner JM, Marley RJ: Genetic differences in the effects of delta-aminolevulinic acid on seizure susceptibility. Experimental Neurology 94: 280-291, 1986.

16. Marks MJ, Stitzel JA, Romm E, Wehner JM, Collins AC: Nicotinic binding sites in rat and mouse brain: Comparison of acetylcholine, nicotine, and alpha-bungarotoxin. Molecular Pharmacology 30: 427-436, 1986.

17. Marley RJ, Gaffney D, Wehner JM: Genetic influences on GABA-related seizures. Pharmacology Biochemistry and Behavior 24: 665-672, 1986.

18. Marley RJ, Miner LL, Wehner JM, Collins AC: Differential effects of central nervous system depressants in long-sleep and short-sleep mice. Journal of Pharmacology and Experimental Therapeutics 238: 1028-1033, 1986.

19. Marley RJ, Wehner JM: GABA enhancement of flunitrazepam binding in mice selectively bred for differential sensitivity to ethanol. Alcohol and Drug Research 7: 25-32, 1986.

20. Wehner JM, Murphy-Erdosh C, Smolen A, Smolen TN: Genetic variation in paraoxonase activity and sensitivity to diisopropylphosphofluoridate in inbred mice. Pharmacology Biochemistry and Behavior 28: 317-320, 1987.

21. Freund RK, Marley RJ, Wehner JM: Differential sensitivities to seizure-inducing and electrophysiological effects of bicuculline in three mouse strains. Brain Research Bulletin 18: 657-662, 1987.

22. Freund RK, Wehner JM: Strain-selective effects of nicotine on electrophysiological responses evoked in hippocampus from DBA/2Ibg and C3H/2Ibg mice. Journal of Neurogenetics 4: 75-86, 1987.

23. Marley RJ, Wehner JM: Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice. Life Sciences 40: 2215-2224, 1987.

24. Upchurch M, Wehner JM: Effects of chronic diisopropylfluorophosphate treatment on spatial learning in mice. Pharmacology, Biochemistry, and Behavior 27: 143-151, 1987.

25. Collins AC, Romm E, Wehner JM: Nicotine tolerance: An analysis of the time course of its development and loss in the rat. Psychopharmacology 96: 7-14, 1988.

26. Freund RK, Jungschaffer DA, Collins AC, Wehner JM: Evidence for modulation of GABAergic neurotransmission by nicotine. Brain Research 453: 215-220, 1988.

27. Marley RJ, Freund RK, Wehner JM: Differential response to flurazepam in long-sleep and short-sleep mice. Pharmacology Biochemistry and Behavior 31: 453- 458, 1988.

28. Marley RJ, Stinchcomb A, Wehner JM: Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep mice. Life Sciences 43: 1223-1231, 1988.

29. Martin BJ, Marley RJ, Miner LL, Wehner JM: Classical genetic analysis of GABA-related seizures. Pharmacology Biochemistry and Behavior 29: 501-507, 1988.

30. Martin B, Wehner JM: Influence of genotype on nicotine-induced increases of plasma corticosterone in mice as a result of acute nicotine pretreatment. Pharmacology Biochemistry and Behavior 30: 1065-1070, 1988.

31. Pelleymounter MA, Schlesinger K, Wehner JM, Hall ME, Stewart JM: Nigral 5-HT and substance P-induced enhancement of passive avoidance retention. Behavioral and Brain Research 29: 159-172, 1988.

32. Upchurch M, Pounder JI, Wehner JM: Heterosis and resistance to DFP effects on spatial learning in C57BL X DBA hybrids. Brain Research Bulletin 21: 499-503, 1988.

33. Upchurch M, Wehner JM: DBA/2Ibg mice are incapable of cholinergically-based learning in the Morris water task. Pharmacology Biochemistry and Behavior, 29: 325-330, 1988.

34. Upchurch M, Wehner JM: Differences between inbred strains of mice in Morris water maze performance. Behavior Genetics 18: 55-68, 1988.

35. Wehner JM, Upchurch M: The effects of chronic oxotremorine treatment on spatial learning and tolerance development in mice. Pharmacology Biochemistry and Behavior 32: 543-551, 1989.

36. Bowers, BJ, Wehner JM: Interaction of ethanol and stress with the GABA/BZ receptor in LS and SS mice. Brain Research Bulletin 23: 53-59, 1989.

37. Peris J, Wehner JM, Zahniser NR: [35S]TBPS binding sites are decreased in the colliculi of mice with a genetic predisposition to bicuculline-induced seizures. Brain Research 503: 288-295, 1989.

38. Stinchcomb A, Bowers BJ, Wehner JM: The effects of ethanol and Ro 15-4513 on elevated plus-maze and rotarod performance in Long-Sleep and Short-Sleep mice. Alcohol 6: 369-376, 1989.

39. Upchurch M, Wehner JM: Inheritance of spatial learning ability in inbred mice: A classical genetic analysis. Behavioral Neuroscience 103: 1251-1258, 1989.

40. Wehner JM, Martin BJ, Marley RJ, Pounder JI: Behavioral studies of GABAergic responses in LS and SS mice: Are ethanol sensitivity and responses to GABAergic agents regulated by common mechanisms- In RA Deitrich, AA Pawlowski (eds.), Initial Sensitivity to Alcohol NIAAA Research Monograph-20. Washington, DC: US Government Printing Office, 1990. Pp. 345-379.

41. Wehner JM, Sleight S, Upchurch M: Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Research 523: 181-187, 1990.

42. Collins AC, Romm E, Wehner JM: Dissociation of the apparent relationship between nicotine tolerance and up-regulation of nicotinic receptors. Brain Research Bulletin 25: 373-379, 1990.

43. Upchurch M, Wehner JM: Effects of N-methyl-D-aspartate antagonism on spatial learning ability in mice. Psychopharmacology 100: 209-214, 1990.

44. Wehner JM, Pounder JI, Bowers BJ: The use of recombinant inbred strains to study drug response sensitivities. J. of Addictive Diseases 10: 89-107, 1991.

45. Bowers BJ, Bosy TZ, Wehner JM: Adrenalectomy increases bicuculline-induced seizure sensitivity in long-sleep and short-sleep mice. Pharmacology Biochemistry and Behavior, 38:593-600, 1991.

46. Paylor R, Rudy JA, Wehner JM: Acute phorbol ester treatment improves learning performance in rats. Behavioral Brain Research, 45: 189-193, 1991.

47. Bowers BJ, Wehner JM: Adrenalectomy and stress modulate GABAA receptor function in LS and SS mice. Brain Research, 576: 80-88, 1992.

48. de Fiebre CM, Marley RJ, Miner LJ, Colley NE, Wehner JM, and Collins AC: Classical genetic analyses of responses to sedative-hypnotic drugs in crosses derived from long-sleep and short-sleep mice. Alcoholism: Clinical and Experimental Research, 16: 511-521, 1992.

49. Minnick SA, Wehner JM: The rate of ethanol absorption is influenced by corticosterone in Long-sleep and Short-sleep mice, Alcoholism: Clinical and Experimental Research, 16: 460-465, 1992.

50. Wehner JM, Pounder JI, Parham C, Collins AC: A recombinant inbred strain analysis of sleep-time responses to several sedative-hypnotics, Alcoholism: Clinical and Experimental Research, 16: 522-528, 1992.

51. Bowers BJ, Wehner JM: Biochemical and behavioral effects of steroids on GABAA receptor function in Long-sleep and Short-sleep mice. Brain Research Bulletin, 29: 57-68, 1992.

52. Silva AJ, Paylor R, Wehner JM, Tonegawa S: Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257: 206-211, 1992.

53. Silva AJ, Wang Y, Paylor R, Wehner JM, Stevens CF, Tonegawa S: Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harbor Symposia on Quantitative Biology Vol. LVII: 527-539, 1992.

54. de Fiebre NC, Marley RJ, Wehner JM, Collins AC: Lipid solubility of sedative-hypnotic drugs influences hypothermic and hypnotic responses of long-sleep and short-sleep mice. Journ. Pharmacol. Exper. Ther. 263: 232-240, 1992.

55. Fordyce DE, Wehner JM: Determination of Hippocampal Protein kinase C using a frozen tissue method: Comparison of activity in pre and postsynaptic activity in C57BL/6 and DBA/2 mice. Biochem. Biophys. Res. Comm., 188: 690-694, 1992.

56. Paylor R, Morrison SK, Rudy JW, Waltrip LT, Wehner JM: Brief exposure to an enriched environment improves performance on the Morris water task and increases hippocampal protein kinase C activity in young rats. Behav. Brain Res., 52: 49-59, 1992.

57. Wehner JM, Bosy TZ, Waltrip LA: Solubilization of benzodiazepine receptors from Long- and Short-Sleep mice. Pharmacology, Biochemistry, Behavior, 44: 133-139, 1993.

58. Bowers BJ, Parham CL, Sikela JM, Wehner JM: Isolation and nucleotide sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme. Gene, 123: 263- 265, 1993.

59. Paylor R, Baskall L, Wehner JM: Behavioral dissociations between C57BL/6 and DBA/2 mice on learning and memory tasks: A hippocampal-dysfunction hypothesis. Psychobiology, 21:11-26, 1993.

60. Fordyce DE, Wehner JM: Effects of aging on spatial learning and hippocampal protein kinase C in mice. Neurobiology of Aging, 14: 309-317, 1993.

61. Fordyce DE, Wehner JM: Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice. Brain Research, 619: 111-119, 1993.

62. Silva AJ, Paylor R, Wehner JM, Tonegawa S: Technical Comments: Spatial learning in mutant mice. Science, 262: 760-762, 1993.

63. Abeliovich A, Paylor R, Chen C, Kim JJ, Wehner JM, Tonegawa S: PKC-gamma mutant mice exhibit mild deficits in spatial and contextual learning. Cell, 75:1263-1271, 1993.

64. Collins AC, Wehner JM, Wilson WR: Animal models of alcoholism: genetic strategies and neurochemical mechanisms. Biochem. Soc. Symp., 59:173-191, 1993.

65. Miller S, Wehner JM: Cholesterol treatment facilitates spatial learning performance in DBA/2Ibg mice. Pharmacology, Biochemistry, and Behavior, 49:257-261, 1994.

66. Paylor R, Johnson RS, Papaioannou V, Spiegelman BM, Wehner JM: Behavioral assessment of c-fos mutant mice. Brain Research, 651:275-282, 1994.

67. Paylor R, Tracy R, Wehner JM, Rudy JW: DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behavioral Neurosciences, 108:810-817, 1994.

68. Fordyce DE, Bhat RV, Baraban JM, Wehner JM: Genetic and activity-dependent regulation of Zif268 expression: Association with spatial learning. Hippocampus, 4:559-568, 1994.

69. Fordyce DE, Clark VJ, Paylor R, Wehner JM: Enhancement of hippocampally-mediated learning and protein kinase C activity by oxiracetam in learning-impaired DBA/2 mice. Brain Research, 672:170-176, 1995.

70. Harris RA, McQuilkin SJ, Paylor R, Abeliovich A, Tonegawa S, Wehner JM: Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors. Proc. Natl. Acad. Sci. USA, 92:3658-3662, 1995.

71. Minnick SA, Miller SL, Wehner JM: The effects of acute stress on ethanol absorption in LS and SS mice. Alcohol, 12:257-263, 1995.

72. Cao W, Wehner JM, Collins AC: Chronic intragastric infusion produces tolerance to ethanol in LS and SS mice. Alcohol, 12:241-246, 1995.

73. Bowers BJ, Christensen SC, Pauley JR, Paylor R, Yuva L, Dunbar SE, Wehner JM: Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice. Journal of Neurochemistry, 64:2737-2746, 1995.

74. Wehner JM, Bowers BJ: The use of transgenics, null mutants, and antisense approaches to study ethanol's actions. Alcoholism: Clinical and Experimental Research, 19:811-820, 1995.

75. Bennett CM, Fordyce D, Rose GM, and Wehner JM: Chronic sodium azide treatment decreases membrane-bound protein kinase C activity in the rat hippocampus. Neurobiology of Learning and Memory, 64:187-190, 1995.

76. Tonegawa S, Li Y, Erzurumlu RS, Jhaveri S, Chen C, Goda Y, Paylor R, Silva AJ, Kim JJ, Wehner JM, Stevens CF, and Abeliovich A: The gene knockout technology for the analysis of learning and memory, and neural development. In ACH Yu, LF Eng, UJ McMahan, H Schulman, EM Shooter, and A Stadlin (eds.), Progress in Brain Research, Vol. 105. New York: Elsevier Science BV, 1995. Pp. 3-14.

77. Hiller-Sturmhöfel S, Bowers BJ, Wehner JM: Genetic engineering in animal models. Alcohol Health & Research World, 19:206-213, 1995.

78. Wehner JM, Bowers BJ, Paylor R: The use of null mutant mice to study complex learning and memory processes. Behavior Genetics, 26:301-312, 1996.

79. Christensen SC, Johnson TE, Markel PD, Clark VJ, Fulker DW, Corley RP, Collins AC, and Wehner JM: Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice. Alcoholism: Clinical and Experimental Research, 20:543-550, 1996.

80. Forrest D, Hanebuth E, Smeyne RJ, Everds N, Stewart CL, Wehner JM, Curran T: Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor ß: evidence for tissue-specific modulation of receptor function. The EMBO Journal, 15:3006-3015, 1996.

81. Wehner JM, Logue SF, Owen, EH: Issues for examining complex learning in mice. In: What's Wrong with My Mouse: New Interplays Between Mouse Genetics and Behavior (1996 Short Course 1 Syllabus), JS Takahashi (ED), pp. 39-49. Washington DC: Society for Neuroscience, 1996.

82. Paylor R, Baskall-Baldini L, Yuva L, Wehner JM: Developmental differences in place-learning performance between C57BL/6 and DBA/2 mice parallel the ontogeny of hippocampal protein kinase C. Behavioral Neuroscience, 1996, 110:1415-1425.

83. Wehner JM and Silva AJ: Importance of strain differences in evaluations of learning and memory processes in null mutants. Mental Retardation and Developmental Disabilities Research Reviews, 1996, 2:243-248.

84. Logue SF, Paylor R, Wehner JM: Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task. Behavioral Neuroscience, 1997, 111:104-113.

85. Crawley JN, Belknap JK, Collins A, Crabbe JC, Frankel W, Henderson N, Hitzemann RJ, Maxson SC, Miner LL, Silva AJ, Wehner JM, Wynshaw-Boris A, Paylor R: Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology, 1997, 132:107-124.

86. Owen EH, Christensen SC, Paylor R, Wehner JM: Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains. Behavioral Neuroscience, 1997, 111: 292-300.

87. Logue SF, Owen EH, Rasmussen DL, Wehner JM: Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred strains and F1 hybrids: Implications of genetic background for single gene and quantitative trait loci analyses. Neuroscience, 1997, 80: 1075-1086.

88. Owen EH, Logue SF, Rasmussen DL, Wehner JM: Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience, 1997, 80: 1087-1099.

89. Wehner JM, Radcliffe RA, Rosmann ST, Christensen SC, Rasmussen DL, Fulker DW, Wiles M: Quantitative trait locus analysis of contextual fear conditioning in mice. Nature Genetics, 1997, 17: 331-334.

90. Caldarone B, Saavedra C, Tartaglia K, Wehner JM, Dudek BC, Flaherty L: Quantitative trait loci analysis affecting contextual conditioning in mice. Nature Genetics, 1997, 17: 335-337.

91. Lu Y, Wehner JM: Enhancement of contextual fear-conditioning by putative (±)-a--amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-D-aspartate (NMDA) receptor antagonists in DBA/2J mice. Brain Research, 1997, 768: 197-207.

92. Banbury Conference on Genetic Background in Mice: Mutant mice and neuroscience: Recommendations concerning genetic background. (Wehner JM, one of 26 contributors to the recommendations in this article.) Neuron, 1997, 19: 755-759.

93. Brandon EP, Logue SF, Adams MR, Qi M, Sullivan SP, Matsumoto AM, Dorsa DM, Wehner JM, McKnight GS, Idzerda RL: Defective motor behavior and neural gene expression in RIIß-protein kinase A mutant mice. J. Neurosci., 1998, 18: 3639-3649.

94. Radcliffe RA, Erwin VG, Wehner JM: Acute functional tolerance to ethanol and fear conditioning are genetically correlated in mice. Alcohol Clin & Exp Res, 1998, 22: 1673-1679.

95. Tecott LH, Logue SF, Wehner JM, Kauer JA: Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice. PNAS, 1998, 95: 15026-15031.

96. Logue SF, Swartz RJ, Wehner JM: Genetic correlation between performance on an appetitive signalled nosepoke task and voluntary ethanol consumption. Alcohol Clin Exp Res, 1998, 22: 1912-1920.

97. Paylor R, Bowers BJ, Wehner JM: The involvement of protein kinase C in hippocampal-dependent learning. In: A Neugebauer (ED.), Macromolecular Interplay in Brain Associative Mechanisms. Pp. 240-249. Singapore, London, River Edge, NJ: World Scientific Publishing, 1998.

98. Logue SF, Owen EH, Wehner JM: Approaches to study the genetic regulation of learning and memory. In: DW Pfaff, WH Berrettini, SC Maxson, TH Joh (eds.), Genetic Influences on Neural and Behavioral Functions. Chap. 25 pp. 459-570; Boca Raton, FL: CRC Press, 1999.

99. Bowers BJ, Owen EH, Collins AC, Abeliovich A, Tonegawa S, Wehner, JM: Decreased ethanol sensitivity and tolerance development in γ-Protein Kinase C null mutant mice is dependent on genetic background. Alcohol Clin Exp Res, 23: 387-397, 1999.

100. Gould TJ, Wehner JM: Nicotine enhancement of contextual fear conditioning. Behav Brain Res, 102: 31-39, 1999.

101. Gould TJ, Wehner JM: Genetic influences on latent inhibition. Behav Neurosci, 113: 1291-1296, 1999.

102. Turri MG, Talbot CJ, Radcliffe RA, Wehner JM, Flint J: High resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mammalian Genome, 10: 1098-1101, 1999.

103. Bowers BJ, Collins AC, Wehner JM: Background genotype modulates the effects of γ-PKC on the development of rapid tolerance to ethanol-induced hypothermia. Addict Biol, 5: 47-58, 2000.

104. Young EA, Owen EH, Meiri KF, Wehner JM: Alterations in hippocampal GAP-43 phosphorylation and protein level following contextual fear conditioning. Brain Res, 860: 95-103, 2000.

105. Wick MJ, Radcliffe RA, Bowers BJ, Mascia MP, Lüscher B, Harris RA, Wehner JM: Behavioural changes produced by transgenic overexpression of ─L and ─S subunits of the GABAA receptor. Eur J Neurosci, 12: 2634-2638, 2000.

106. Bowers BJ, Collins AC, Tritto T, Wehner JM: Mice lacking PKCγ exhibit decreased anxiety. Behav Genet, 30: 111-121, 2000.

107. Radcliffe RA, Lowe MV, Wehner JM: Confirmation of contextual fear conditioning QTLs by short-term selection. Behav Genet, 30: 183-191, 2000.

108. Radcliffe RA, Bohl ML, Lowe MV, Cykowski CS, Wehner JM: Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains. Alcohol: Clin Exp Res, 24: 1335-1342, 2000.

109. Gould TJ, Collins AC, Wehner JM: Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition. Nicotine & Tobacco Research, 3: 17-24, 2001.

110. Vissel B, Royle GA, Christie BR, Schiffer HH, Ghetti A, Tritto T, Perez-Otano I, Radcliffe RA, Seamans J, Sejnowski T, Wehner JM, Collins AC, O’Gorman S, Heinemann SF: The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron, 29:217-227, 2001.

111. Labarca C, Schwarz J, Deshpande P, Schwarz S, Nowak MW, Fonck C, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, Lester HA: Point mutant mice with hypersensitive a-4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proceedings of the National Academy of Science USA, 98: 2786-2791, 2001.

112. Bowers BJ, Elliott, KJ Wehner JM: Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCγ null mutant mice. Pharmacology, Biochemistry and Behavior, 68: 1-12, 2001.

113. Wehner JM, Radcliffe RA, Bowers BJ: Quantitative genetics and mouse behavior. Annual Reviews of Neuroscience 2001, 24:845-67, 2001.

114. Wehner JM, Radcliffe RA: Cued and contextual fear conditioning in mice (Unit 8.5C). In: Current Protocols in Neuroscience 2001, pp. 1-12. John Wiley & Sons: New York, 2001.

115. Bowers BJ, Wehner JM: Ethanol consumption and behavioral impulsivity are increased in PKCγ null mutant mice. Journal of Neuroscience, 21:RC180 (1-5) 2001.

116. Mihalek RM, Bowers BJ, Wehner JM, Kralic JE, VanDoren MJ, Morrow AL, Homanics GE: Neurosteroid resistant GABAA-receptor d subunit knockout mice also have multiple defects in behavioral responses to ethanol. Alcoholism: Clin Exp Res, 25: 1708-1718, 2001.

117. Tecott LH, Wehner JM: Mouse molecular genetic technologies: Promise for psychiatric research. Archives of General Psychiatry, 58: 995-1004, 2001.

118. Smith AM, Wehner JM: Aniracetam improves contextual fear conditioning and increases hippocampal γ-PKC activation in DBA/2J mice. Hippocampus, 12:76-85, 2002.

119. Balogh SA, Owens JC, Butt CM, Wehner JM, Collins AC: Animal models as a tool for studying mechanisms of co-abuse of alcohol and tobacco. Alcoholism: Clinical and Experimental Research, 26: 1911-1914, 2002.

120. Balogh SA, Radcliffe RA, Logue SF, Wehner JM: Contextual fear conditioning in C57BL/6J and DBA/2J mice: Context discrimination and the effects of retention interval. Behavioral Neuroscience, 116: 947-957, 2002.

121. Wehner JM, Balogh SA: Genetic studies of learning and memory in mouse models. In: Plomin R, DeFries J, Craig I, McGuffin P (eds) Behavioral Genetics in the Postgenomic Era, Chapter 7, American Psychological Association, 2003.

122. Hoffman PL, Miles M, Edenberg HJ, Sommer W, Tabakoff B, Wehner JM, Lewohl J: Gene expression in brain: A window on ethanol dependence, neuroadaptation, and preference. Alcoholism: Clinical and Experimental Research, 27: 155-168, 2003.

123. Talbot CJ, Radcliffe RA, Fullerton J, Hitzemann R, Wehner J, Flint J: Fine scale mapping of a genetic locus for conditioned fear. Mammalian Genome, 14:223-230, 2003.

124. Balogh SA, Wehner JM: Inbred mouse strain differences in the establishment of long-term fear memory. Behavioural Brain Research, 140:97-106, 2003.

125. Proctor WR, Poelchen W, Bowers BJ, Wehner JM; Messing, RO; Dunwiddie, TV: Ethanol differentially enhances hippocampal GABAA receptor-mediated responses in PKCγ and PKCε null mice. Journal of Pharmacology and Experimental Therapeutics, 305:264-270, 2003.

Articles in press:

126. Gorski JA, Balogh SA, Wehner JM, Jones KR: Learning deficits in forebrain-restricted BDNF null mutant mice. Neuroscience, in press.

127. Hix DM, Bowers BJ, Miyamoto JH, Wehner JM: Open field activity and EtOH activation of γ-PKC null mutants. Addiction Biology, in press.

128. Wehner JM, Balogh SA: Phenotyping mice for learning and memory: Traditional tasks, modifications of traditional tasks, and the application of new tasks. In: Mouse Behavioral Phenotyping (2003 Short Course 2 Syllabus), JN Crawley (ED), pp. New Orleans, LA: Society for Neuroscience, 2003, in press.