Grants
Empirical research supported by external funds (Funding is annual direct costs.)
Current active support
Testing a Developmental Model of Conduct Problems
1 R01 HD050346-01A1(Rhee)
09/01/07-6/30/12
8.3% acad/0.75 acad
NIH/NICHD
$227,359The main goal of this study is to examine existing data from the Colorado Longitudinal Twin Study to test the developmental propensity model, which advances specific and testable hypotheses regarding the causes of conduct problems.
Variance Component Models for Mapping QTLs
5 R01 EY012562-08 (Hewitt)
09/01/02-08/31/08
10% acad/0.9 acad
NIH/NEI
$290,044 (no cost ext)The goal of this project is to further extend the methodology of variance components analysis to accommodate more general data structures and models that are of practical importance to the design and analysis of modern genetic studies, and to integrate these into a comprehensive software package.
 |
|
|
|
|
|
 |
|
||||
 |
 |
|
|||
 |
|
||||
 |
 |
|
|||
 |
|
||||
 |
|
||||
 |
|
||||
 |
|
||||
 |
|
||||
 |
|
||||
 |
|
||||
 |
 |
 |
|
||
 |
|
||||
Workshop on Methodology of Twin Studies
5 R25 MH019918-15 (Hewitt)
07/01/03-06/30/08
5% acad/0.45 acad
NIH/NIMH
$144,009
33.3% sum/1.0 sumThe major goal of this project is to provide five training and information-sharing workshops for researchers involved in twin and family genetic epidemiology studies wishing to learn the latest methodology for data analysis and experimental design.
Antisocial Drug Dependence: Genetics -Administrative/Educational Core A – Boulder
5 P60 DA011015-10 (Crowley)
08/15/03-04/30/08
NIH/NIDA
(Hewitt)
$37,563 (sub only)
5% acad/0.45 acadThe major goal of the administrative and educational core is to facilitate interactions among an interdisciplinary group of clinicians, behavioral geneticists, and molecular biologists at the Health Sciences Center and Boulder Campus of the University of Colorado. The educational core also supports a postdoctoral research associate position.
Component I: Adolescent Drug/Alcohol Dependence: Genetics and Treatment (Stallings)
$8,863 (sub only)
2.8% acad /0.25 acad
The major goal of Component I is a whole-genome search for chromosomal loci containing genes influencing early-onset dependence on drugs and antisocial behavior.
Component IV: Heritable Early Indicators of Risk for Drug Dependence (Hewitt)$157,205
5% acad/0.45 acad 10.4% sum/0.31 sumThe major goal of Component IV is to use an augmented twin study to understand how genes and environmental influences contribute to vulnerability to drug abuse and antisocial behavior as they develop during adolescence. A second wave of assessments will be conducted with 1300 pairs of twins and their siblings 5 years after the initial interview.
Abnormal Eye Movement in Schizophrenia: Genome-Wide Scan
Subcontract to Inst. for Behavioral Genetics (Hewitt)5 R01 MH066115-04 (Ross)
01/09/04-12/31/08
3% sum/0.09 sum
NIH/NIMH
$16,928The purpose of this subcontract is to assist Dr. Randal Ross in conducting extended pedigree and sibling-pair linkage analyses to detect quantitative trait loci that increase risk for schizophrenia.
The National Longitudinal Study of Adolescent Health
Subcontract to Inst. for Behavioral Genetics
Project V: Gene*Environment Contributions to Drug Use and Problem Behavior Trajectories (Hewitt)5 P01 HD031921-13 (Harris)
01/01/06-12/31/10
33.3% sum/1.0 sum
10% acad/0.9 acad
NIH/NICHD
$ 101,774 (sub only)This data analysis subproject will examine the developmental trajectories of drug use and related behaviors, including conduct problems and risky sexual behavior.
Executive Functions and Self-Regulation: A Twin Study
2 R56 MH063207-06A1 (Hewitt)
06/01/01-05/31/08
15% acad/1.35 acad
15% sum/0.45 sum
NIH/NIMH
$323,389
This study examines: genetic and environmental contributions to stability and change in EFs during the transition from adolescence to young adulthood; the relations among self-regulation abilities in three domains, as well as the genetic and environmental etiologies of individual differences in these self-regulation abilities in early adulthood; and the relationship between EFs and self-regulation in early adulthood.Pending: Grants submitted
Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors
2 P60 DA011015 (Hewitt - Director of Center)
05/01/08-04/30/13
NIH/NIDA
The overall goal of this Comprehensive P60 Center is to contribute to our understanding of the etiology of individual differences in behavioral control or behavioral disinhibition, the relationship of this to drug abuse and the development of dependence, and the role that these play in the propensity for risky behaviors that may result in STDs, including HIV/AIDS.Core A: The Administrative, Educational, and Ethics Core (Hewitt)
$322,817
20% acad/1.8 acadThis Core coordinates integrated research and educational activities, and contributes a novel emphasis on the ethical issues of the research. The core ensures: synergy, multidisciplinary involvement, training and education, and an integral consideration of ethical issues in the design, publication, and interpretation of the research. It co-ordinates the Center Executive Committee and Scientific Advisory Board.
Core B: Data Management, Informatics and Biostatistics (McQueen)
$228,357
12% acad/1.08 acadThis Core has primary responsibility for essential functions of quality control of data collection, data integration, dissemination, and analysis for the Center in response to the needs of the other Cores and Components. It provides expertise in experimental design and analysis of component studies, with an emphasis on projects involving molecular genetic data, and it develops and applies novel statistical and epidemiological approaches to the Center data.
Component 1: Genetics of Adolescent Antisocial Drug Dependence and HIV-Related Risk Factors (McQueen)
$403,973
10% acad/0.90 acadThis component will conduct a genome-wide association study on an existing sample of 1000 adolescent cases and 1000 controls with Substance Dependence, Conduct Disorder, and HIV-related risk behaviors. A replication sample of 600 new adolescents recruited from adolescent substance abuse treatment programs and a control sample of 600 adolescents recruited from a large primary care clinic will be collected. This new sample will be assessed with detailed HIV-risk behavior, substance dependence, and conduct disorder measures.
Component 2: Clinical Family and Community Twin, Family, and Adoption Studies (Stallings)
$462,422
5% acad/0.45 acadComponent 2: This component will provide crucial information regarding: 1) genetic and environmental influences on substance-related behaviors, antisocial behavior, and HIV-risk behaviors; 2) the generality versus specificity of these influences; and 3) genetic and environmental contributions to developmental persistence of these behaviors. This component will complete a third assessment on the center samples, providing critical information regarding developmental patterns of substance-related behavior, including antisocial behavior and HIV-risk behavior.
Affymetrix GeneChip® Scanner for Genetic Analysis of Complex Traits
1 S10 RR021013-01A2 (Hewitt)
04/01/08-03/31/09
no effort equip only
NIH/NCRR
$326,690This proposal is to buy a GeneChip® Scanner 3000 Targeted Genotyping System from Affymetrix®, together with associated equipment and software. This system will allow multiple investigators, studying the genetics of substance abuse and mental health in both humans and animal models, to design high-throughput genotyping, sequencing, and expression assays targeted for their specific genomic areas of interest.
IBSC: Determinants of Executive Function and Dysfunction (Banich)
Subcontract to Inst for Behavioral Genetics (Hewitt)1 P50 MH079485-01A1 (Banich)
09/01/2007-08/31/2012
NIH/NIMH
$143,525 (sub only)
33.3%sum/1.0 sum
Project 4: Genetic Mechanisms of Executive Functions
The goal of this project is to use molecular genetic analyses in concert with computational modeling to begin to specify in more detail how the dopamine system regulates three correlated but separable executive functions - inhibiting prepotent response, updating working memory, and shifting mental sets. We will analyze existing molecular and psychometric data on approximately 800 individual twins who were tested on nine index executive tasks at age 17 and were also tested on general cognitive ability and IQ at age 16.Executive Functions and Self-Regulation: A Twin Study
2 R01 MH063207-06A2 (Hewitt)
12/01/07-11/30/12
15%acad/1.35 acad
15% sum/0.45 sum
NIH/NIMH
$302,402
This twin study will assess, during the transition from adolescence to young adulthood, genetic and environmental contributions to: stability and change in executive functioning: individual differences in self-regulation; and the relationships between executive functions and self-regulation.Genetics of Adolescent Antisocial Drug Dependence (COMRAD)
1 R01 DA012845-01A2 (Hewitt)
04/01/2008-03/31/2013
20% acad/1.8 acad
33% sum/1.0 sum
NIH/NIDA$268,143
This COMRAD proposal continues a multisite collaboration, initiated under DA 012845, to conduct a prospective study to address critical issues in the genetic epidemiology of adolescent onset antisocial drug dependence. We will complete five year follow-up assessments, examine drug use and antisocial behavior trajectories and their predictors, and we will conduct genome wide association analyses of persistent adolescent-onset antisocial drug dependence.Workshop on Methodology of Twin Studies
2 R25 MH019918-16 (Hewitt)
07/01/08-06/30/13
5% acad/0.45 acad
5% sum/0.15 sum
NIH/NIMH
$125,773The major goal of this project is to provide five training and information-sharing workshops for researchers involved in twin and family genetic epidemiology studies wishing to learn the latest methodology for data analysis and experimental design.
Social and Genetic Factors in the Development of Tobacco and Alcohol Dependence (McQueen)
1 R01 (Hill)
7/1/08-6/30/13
5% acad/0.45 acad
16.7% sum/.50 sum
NIH/NIDA
$60,527 (sub only)
The primary responsibility of the IBG component is to genotype and analyze the collected DNA. In particular, IBG will be involved in the processing and genotyping of DNA as well as management and statistical analyses of the genotype data.Item Response Theory-Based Approaches to Longitudinal and Multi-Group Data
1 R21 (Gelhorn)
7/1/08-6/30/10
NIHSubcontract to Inst. for Behavioral Genetics
(Hewitt) 5% acad/0.45 acad
$29,429 (sub only)
5%sum/0.15 sumThe goal of this project is to use Item Response Theory-based statistical methodology to facilitate the analysis of genetically informative longitudinal data with developmentally appropriate phenotypic measures.
Earlier Support
NIH/NIDA "Genetics of Adolescent Antisocial Drug Dependence," Sub-component to the Inst. for Beh. Genetics, DA 012845, 09/15/00-02/28/06, Co-Investigator, $75,377, 16.5% summer effortNIH/NIAAAB"NYS Family Study: Problem Alcohol Use and Problem Behavior," Sub-component to the Inst. for Behav. Genetics, AA 011949, 09/30/00-08/31/05, Principal Investigator, $213,364, 6.67% academic year effort
NIH/NIAAAB"Alcohol Dependence: Integrating Genetic & fMRI Methods," AA 011473, 05/05/05-06/30/10, Co-Investigator, $330,505, 5% academic year effort (Grant transferred to New Mexico when PI moved.)
NIH/NIDAB"Progress of craving and addiction: Genetic factors," DA14642, 12/01/01-11/30/06, Co-Investigator, $250,000
NIH/NIAAAB "NYS Family Study: Problem Alcohol Use and Problem Behavior," AA11949, 09/30/00-08/31/06, Co-Principal Investigator, annual direct costs $940,896 (no cost extension).
NIH/NICHDB"Determinants of Behavioral Development in Children," HD 010333, 06/01/03-05/31/07, Co-Investigator, $244,145, 16.7% summer effort
NIH/NIAAAB"Genetic Association and Stratification," AA 014250, 09/30/03-08/31/06, Co-Investigator, $125,000, 5% academic year effort and 5% summer effort
NIH/NICHDB"Behavioral Genetic Analysis of Adolescent Health Risk," Sub-component to the Inst. for Behav. Genetics, HD 031921, 07/01/02-01/31/04, Principal Investigator, $105,314, 5% academic year effort & 5% summer effort
NIH/NICHDB"Research TrainingBDevelopmental Behavioral Genetics," Competitive Renewal, 2732HD07289, 09/01/00-04/30/05, Principal Investigator, annual direct costs $169,951
NIH/NIAB"Biometrical Analysis of Personality in Adulthood," AG 17949, 04/01/00-03/31/03, Co-Principal Investigator, annual direct costs $75,000NIMHB"Transition into Early Adolescence," MH43899 (renewal), 03/01/00-11/30/03, Principal Investigator, annual direct costs $205,682
John D. and Catherine T. MacArthur FoundationB"Family Influences on Behavioral Development," 99-59585 HCD, 11/01/99-12/31/01, Principal Investigator, $42,000
NIH/NEIB"Variance Components Models for Mapping QTLs," EY 12562, 12/07/98-11/30/02, Principal Investigator, annual direct costs $186,133, 15% academic year effort
NIMHC"Workshop on Methodology of Twin Studies," MH19918, (renewal), 09/01/98-08/31/03, Principal Investigator, $85,203
NIH/NICHD--"Nature and Nurture in Social Demography: An Adoption Study," HD 36773, 08/01/98-05/31/03, Co-Investigator, $209,659
NICHD--"Determinants of Behavioral Development in Children," HD10333, (competitive renewal), 06/01/98-05/31/03, Co-Investigator, $215,776
The William T. Grant Foundation--"Origins of Successful and Unsuccessful Transitions to Adulthood: The Colorado Adoption Project (CAP)," 98162094, 06/01/98-05/31/01, Principal Investigator, $109,368
NIDA--"Antisocial Drug Dependence: Genetics and Treatment," DA11015, 08/01/97-06/30/02:
"Component I: Adolescent Drug/Alcohol Dependence: Genetics and Treatment," Principal Investigator, Boulder Component, $49,732 (sub only), 5% academic year effort
"Component IV: Heritable Early Indicators of Risk for Drug Dependence," Principal Investigator, $173,136 (sub only)
"Administrative/Educational, Core A, UCB" Co-Investigator, $24,347
"Genetics and Treatment, Assessment Core B, UCB" Principal Investigator, $19,554
Veteran's Administration, Research Center for Basic and Clinical Studies of Alcoholism--"Human Genetics Core" and "Heritable Early Indicators of Alcohol Abuse" components, V554P-3828/3829, 07/1/96-03/01/99, Principal Investigator, $76,500 (sub only)
NICHD--"A Twin/Adoption Study of Development in Middle Childhood," HD 18426-15, 06/01/96-05/31/99, Co-Investigator, $44,436 (sub only)
NIMH--"Workshop on Methodology of Twin Studies," MH19918, 09/01/95-08/31/98, Principal Investigator, $61,914
NIMH--"Transition into Early Adolescence: A Twin/Adoption Study," MH43899, 12/01/94-11/30/99, Principal Investigator, $260,437
NIMH--"Adolescent Behavioral Development: A Twin Study," MH45268, (renewal) 05/01/94-04/30/99, Principal Investigator (PI-ship transferred to L.J. Eaves following my relocation to Colorado), annual direct costs $548,638 rising to $758,569. Priority score 117 in top 3%, 1989‑94. 50% effort. Current effort, 15% academic year, with L.J. Eaves PI, subcontracted through University of Colorado to Hewitt, approx $125,000 over five years, $26,250 total, $18,293 direct (sub only)
John D. and Catherine T. MacArthur Foundation--"MacArthur Longitudinal Twin Study: A Proposal to Study Individual Differences in Adaptation Processes and Outcomes at Seven Years," 93-24177A, 07/01/93-06/30/00, Principal Investigator, $271,349
NICHD--"Determinants of Behavioral Development in Children," HD10333, 06/01/93-05/31/98, Co-Investigator, $171,257
NIDA--"Adolescent Substance Abuse and Their Families," DA05131, Component 2 (PI:Fulker), Drug Abuse Research Center (PI:Defries), 1993-1997, Hewitt Co-Investigator, total direct costs $607,082.
NIMH--"Workshop on Methodology of Twin Studies," MH19687, 09/92-08/94, Principal Investigator, annual direct costs $40,000
Carman Trust for Scientific Research--"Genetics and Development of Adolescent Mental Health," Principal Investigator, PI-ship transferred to J. Meyer following my relocation to Colorado in 1992, annual direct costs $34,000.
NIMH--"Workshop on Twin Methodology," MH19392, 1990--short term training grant, Principal Investigator, (Priority Score in top 5%) cost $23,359
NIAAA--"Personality and Clinical Psychobiology: Genetics," AA08672, 1990-1994, 25% effort, Principal Investigator, annual direct costs $204,773
NHLBI--"Childhood Passive Smoking: Cohort Study of Cardiac Risk," HL38878, 04/01/89‑94, Co-Investigator, annual direct costs $75,027
NHLBI--"Longitudinal Twin Study: Cohort Study of Blood Pressure," HL31010, 08/88‑07/93, Co‑Investigator, annual direct costs $460K
NIAB"Genetic Models of Development and Aging," AG04954, (renewal), 07/88-06/93, Co‑Investigator, annual direct costs $104K
NIGMB"Resolving Power of Kinship Analysis for Genetic Research," GM30250, 02/86-01/91, Co‑Investigator, annual direct costs $62K
Neuropsychological investigations of children at high risk for schizophrenia: extension. Mental Health Foundation support, 1986. Stlg 5177.
During the years 86‑88, I was an investigator for NIH grants to study Genetic Models of Development and Aging (AG‑04954, 7/84 ‑ 6/88; Annual support $49,211), Biological and Cultural Determinants of Alcohol Consumption (AA‑06781, 8/85 ‑ 7/89; Annual support $95,168), Genetic and environmental influences on anxiety and depression (MH‑40828, 2/86 ‑ 1/90; Annual support $396,181), Resolving Power of Kinship Analysis for Genetical Research (GM‑30250, 2/86 ‑ 1/91; Annual support $75,115).
NIAAAB"Biological and Cultural Determinants of Alcoholism," AA06781, 08/85-07/89, Co‑Investigator, annual direct costs $116K
Genetic and environmental analysis of cardiac reactivity and hypertension. MRC project grant jointly with Drs. D. Carroll (PI), K. Last and Professor J.L. Jinks. 1984‑1987. Stlg 88,627.
Neuropsychological investigations of abnormal interhemispheric integration and anomalous lateralization of function in children at high risk for schizophrenia. Research grant from Mental Health Foundation. 1984‑1986. Stlg 22,447.
Genetic and environmental determinants of cardiac reactivity and hypertension. Supported by project grant from the (British) Medical Research Council, 1982‑1983, jointly with Dr. Carroll (PI) and K. Last. Stlg 8,526
