Massachusetts Institute of Technology: 9/66 - 6/70 B.Sc. (Life Science)
University of Washington: 9/70 - 3/75 Ph.D. (Genetics)
President Elect, President. Past President American Ageing Association, 2005-2008
Presidential Appointee, Task Force on Publications, Gerontological Society
of America, 2001 - 2003, 2005.
Program Committee for the Biological Sciences, Gerontological Society of America,
1997
Member of the Permanent Faculty, Summer Training Courses in Experimental Aging
Research, 1994 - 1996
Chair-Elect, Chair, and Past Chair, Biological Sciences Section, Gerontological
Society of America, 1990-1993
National Scientific Advisory Council, American Federation for Aging Research,
1991-present
Membership and Fellowship Committee, Biological Sciences Section, Gerontological
Society of America, 1986-1989
Publications Committee, Biological Sciences Section, Gerontological Society
of America, 1986-1989
Organizer of Symposium for the Annual American Aging Association; May 31 – June 03 2008, Boulder, CO.
Co-Organizer with Drs. James Curtsinger and David Harrison, Aug 2 - 8, 2000,
Third International Conference on Genetic Effects on Aging, Jackson Laboratory,
Bar Harbor, ME
Organizing Committee, "The Biology of Aging- A Molecular Viewpoint,"
May 1994, Geriatric Center, St. Louis, MO
Co-Organizer with Dr. Caleb Finch, March 1993 Keystone Symposium on the Molecular
Biology of Aging, Keystone, CO
Chair of Organizing Committee for Biological Sciences, November 1991 Gerontological
Society of America, San Francisco, CA
Co-Organizer with Dr. Caleb Finch, UCLA Symposium on the Molecular Biology
of Aging, March 1989, Santa Fe, NM
52nd Annual Meeting of the Gerontological Society of America, November 19-23,
1999, San Francisco, CA.: Gerontogenes through evolution: nematode,
mouse, human.
52nd Annual Meeting of the Gerontological Society of America, November 19-23,
1999, San Francisco, CA.: From daf-2 to the insulin receptor:
does the dauer pathway truly mimic CR in mammals?
European Science Foundation meeting on the Biology of Ageing, May 6-10, 2000,
Spa, Belgium: Gerontogenes mediate health and longevity in nematodes
through increasing resistance to environmental toxins and stressors.
American Aging Association, June 2, 2000, Boston MA: Changes in transcript
prevalence with age in a nematode worm.
Third International Conference on Genetic Effects on Aging August 7, 2000,
Bar Harbor, ME: "Analysis of longevity genes in Caenorhabditis elegans
points to increased response to stress as key for increased longevity."
Course on the Molecular Biology of Aging, August 14, 2000, Marine Biology
Laboratory, Woods Hole, MA: Increased resistance to environmental
stressors and diseases of aging: common-ground among all gerontogenes.
Australian Society of Cellular and Molecular Gerontology, March 27, 2001,
Melbourne, Australia: Increased resistance to environmental stressors
and diseases of aging: common-ground among all gerontogenes.
Gordon Conference on the Biology of Aging, July 22 – 26, 2001, Oxford,
UK: Microarray analysis of normal aging in Caenorhabditis elegans.
Society for the Study of Inborn Errors of Metabolism, Sept 4-7, 2001, Prague,
Czech Republic: Longevity genes in the nematode C. elegans
also increase resistance to stress and prevent disease.
Comparative Biology of Aging Workshop, Feb. 6, 7, 2002, Washington D.C. The
Insulin/IGF-1 pathway in C. elegans: conservation of signaling
cassette; apparent divergence of signal outcome.
Second Euresco Conference on Biological Ageing, Spetses Greece, May 18-22,
2002, "The aging program: an organismic response to living?"
Third Longevity Consortium Meeting, Annapolis Md., July 14 – 16, 2002,
The ‘aging program’ is an organismic response to life.
55th Annual Meeting of the Gerontological Society of America, November 22-25,
2002, Boston, MA: C. elegans, The Promise and The Reality".
56th Annual Meeting of the Gerontological Society of America, at the Public Policy Committee Symposium: “The Genie’s Out of the Bottle: Moral, Ethical, and Societal Implications of the Search for the Fountain of Youth”, November 22, 2003, San Diego CA: “Advances in genetics research promote development of a drug for life extension”.
Robert W. Kleemeier Award Lecture, 56th Annual Meeting of the Gerontological Society of America, November 22, 2003, San Diego CA: “Genes, phenes, and dreams of immortality”.
56th Annual Meeting of the Gerontological Society of America, At the Presentation of the Longevity Prize of the Foundation IPSEN to J. Vaupel, November 22, 2003, San Diego CA: “Genetics of Longevity”.
Biodemography of Survival and Longevity, Duke University, March 11-13, 2004, Raleigh NC: "Revealing hidden heterogeneity underlying mortality deceleration".
Functional Genomics Conference of Ageing, April 28 - May 1, 2004, Crete, Greece, “The age-1 pathway specifies response to hard times”.
33rd Annual Meeting of the American Aging Association, June 4-7, 2004, Tampa FL: “Metabolism and stress resistance in age mutants of C. elegans ”.
University of Nebraska – Lincoln’s Redox Biology Center, Oct. 1, 2004, Lincoln NE: “Resistance to reactive oxidants in longevity mutants of C. elegans”.
International Meeting on C. elegans, June 25 – 29, 2005, Los Angeles, CA: “Stochastic Effects Make a Big Difference in How Long You Will Live (If You Are a Worm)”.
Conference on Genetics of Healthy Aging (GEHA), July 6 – 9, 2005, Bologna, Italy: “Genes, Environment and Chance Determine Longevity.”
Nutrient Control of Gene Expression and Cell Signaling, August 3 - August 4, 2005, Tucson AZ: “Nutrient Specification of Longevity in C. elegans.”
Buck Institute 2005 Symposium, Pharmacology of Lifespan Extension, October 6-8, Novato, CA: "Genes, environment and especially chance determine longevity."
2nd Symposium on The Role of Mitochondria in Conserved Mechanisms of Aging, April 6, 2006, Frankfurt, Germany. “Genes, Environment and Chance – All Play a Role in Determining Life Span; How Much?
11th Annual Genetics & Ethics in the 21st Century Conference, July 21 – 23, 2006, Aspen, CO. “Life Span Extension or Immortality: The Reality and the Hype”
International Association of Gerontology, 5th European Congress of Biogerontology, Istanbul, Turkey, September 16-20, 2006, “Conservation of gene function?” contrasting the IGF-1 and mitochondrial longevity genes of C. elegans”.
Austrian Biochemical Society September 25 – 27, 2006, Salzburg, Austria. “The Roles of Genes, Environment and Chance in Determining Life Span.”
Evolutionary Demography Workshop, October 23 – 25, 2006, Durham, NC. “Environmental and stochastic determinants of longevity explain most of the variation in nematode life-span.”
3rd International Friedreich’s Ataxia Scientific Conference, November 10 – 12, 2006, Bethesda, MD. “A Nematode Model for Friedreich’s Ataxia”
59th Annual Scientific Meeting of The Gerontological Sciety of America, November 16 – 20, 2006, Dallas, TX. “How Far to Immortality? Facts from Research in Invertrebrates.”
European Conference on Aging, November 28 – 30, 2006, Innsbruck, Austria. “Stochastic Aspects of Programmed Aging”
Conference on Research Frontiers of Social, Environmental and Genetic Determinants of Healthy Longevity, December 19 – 21, 2006, Beijing, China. “Genetics of Longevity in C. elegans”.
Molecular Basis of Aging, April 11-15, 2007, Titisee (Germany), “Epigenetic and stochastic factors in C. elegans longevity”.
Summit for Systems Biology, June 5-7, 2007, Richmond, VA, “Genetics of Aging in C. elegans”.
Ben Hall Symposium, University of Washington, Seattle, WA, August 22-25, 2007, “Genes, environment or chance – Roles in the specification of life span, a C. elegans story.”
MiMage Summer Course, Les Diablerets, Switzerland, September 18-22, 2007, “Genes, environment, and chance in aging and life span:How much of each?”
Gordon Research Conference, Les Diablerets, Switzerland, September 23-28, 2007, ”Worm regulation of stress resistance”.
20th Annual AFAR Grantee Conference, New York City, October 1-2, 2007, “A Biomarker of Longevity Involves Response to Stress.”
Summit on Cognitive Aging, Washington D.C. October 9 – 11, 2007, “Genetic and Epigenetic Factors in Age Related Cognitive Function.”
GEHA Training course on Genetic Data Analysis, Rostock, Germany, November 11-13, 2007. “Biodemography in a Model System: The Nematode C. Elegans.”
Symposia Related to QTL-Mapping of Alcoholism and Related Traits
1996 Gordon Research Conference on Alcohol, January 7-12, 1996, Oxnard, CA:
Identifying, Confirming, and Cloning Genes Specifying Sensitivity
to Ethanol in LS and SS Mice.
The Fifth International Conference on Molecular and Cellular Mechanisms of
Anaesthesia, June 18-20, 1997, Calgary, Alberta. Presentation delivered by
Dr. Victoria Simpson, a major collaborator.
Veteran’s Administration Workshop on QTLs and Alcohol Action, September
18-20, 1997, Cannon Beach, OR: Whither QTLs, After the Mapping.
Member, Extramural Scientific Advisory Board, Advisory on Genetics Portfolio,
National Institute on Alcohol Abuse and Alcoholism, Nov. 4, 5, 1997, Washington
D.C.: Quantitative Trait Loci for Alcohol-Related Behaviors in Non-Human
Mammals.
National Institute on Alcohol Abuse and Alcoholism Workshop on QTL Mapping;
August 20-21, 1998, Bethesda, MD: Sedation.
2000 Keystone Symposium on the Genetics of Alcoholism and Substance Abuse,
Jan. 23-28, 2000, Tahoe City, CA.: Uncovering genes for neurosensitivity
to ethanol and general anesthetics.
National Institute on Alcohol Abuse and Alcoholism Workshop on QTL Endgame:
Strategies for Identifying Genes Influencing Alcohol-Related Behavior; Nov.
30 – Dec. 1, 2000, Rockville, MD: QTL ID to gene ID for alcohol’s
hypnotic action.
Keystone Symposia on Natural Variation and Quantitative Genetics in Model
Organisms, Jan. 8 - 13, 2004, Breckenridge, CO: "QTLs in mice and worms;
use of recombinant inbred strains."
38th Winter Conference on Brain Research, Jan. 22 – 28, 2005, Breckenridge, CO: “Novel quantitative trait genes (QTGs) for the sedative-hypnotic drug dependence, withdrawal, and sensitivity.”
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INVITED SEMINARS (since1998):
University of California at Los Angeles, January 29, 1998, Los Angeles, CA:
Gerontogenes in the worm and relevance to mammalian aging.
School of Pharmacy, University of Colorado Health Sciences Center, October
22, 1998, Denver CO: Life extension as resistance to stress: toward
a molecular description in C. elegans.
Department of Molecular Life Science, Tokai University School of Medicine,
October, 27, 1998, Isehara, Kanagawa, Japan, Life extension as resistance
to stress: toward a molecular description in C. elegans.
Department of Aging Angiology, Shinshu University School of Medicine, November
4, 1998, Asahi, Matsumoto, Japan: Life extension as resistance to stress:
toward a molecular description in C. elegans.
Lawrence Berkeley National Laboratory, December 8, 1998, Berkeley, CA: Gerontogenes
in the nematode and their role in the response to stress.
Medical Genetics Program, University of Colorado Health Sciences Center, May
13, 1999, Denver, CO: Molecular genetic approaches to slowing organismic
aging and extending healthy life.
Department of Physiology, University of Pennsylvania, School of Medicine, Oct.
21, 1999, Philadelphia, PA: The role of stress resistance in the specification
of life extension in C. elegans.
Department of Biology, University of North Carolina at Chapel Hill, Oct. 22,
1999, Chapel Hill, NC: The role of stress resistance in the specification
of life extension in C. elegans.
Department of Environmental, Population and Organismic Biology, University
of Colorado at Boulder, Sept. 15, 2000: The role of stress resistance
in the specification of life extension in the nematode C. elegans.
Molecular, Cellular and Developmental Biology, University of Colorado, Sept.
28, 2000, Boulder, CO: Mouse models of human alcoholism: genes underlying
ethanol neurosensitivity.
NIAAA QTL Mapping Workshop, Bethesda, MD, Nov. 30, 2000 "QTL ID to Gene
ID for alcohol's hypnotic action".
Neurogenetics, Inc., San Diego, CA, Dec. 7, 2000 Potential clinical
relevance of daf-16 homologs.
Alcohol Research Center, University of Texas at Austin, TX, March 5, 2001,
Mouse models of human alcoholism: genes underlying hypnotic neurosensitivity
to ethanol.
Alcohol Research Center, Wake Forest University, Greenboro, NC, April, 2001,
Mouse models of human alcoholism: genes underlying ethanol hypnotic
neurosensitivity.
Roche Bioscience, Palo Alto, CA, April 25, 2001, Mapping QTLs for alcohol
and drug sensitivity in mice.
University of Rochester, Rochester, NY, Shock Center on Aging, Sept 10, 2001,
Genetic analysis of aging mutants in C. elegans reveals an insulin/IGF-1
pathway regulating life extension and stress resistance; are there human applications?
Fitzsimons BioTechnology Park, Aurora, CO, Sept 26, 2001, Finding the
longevity gene…in Colorado.
Department of Psychology, University of Colorado at Boulder, Nov. 26, 2001:
Playing the gene game to understand aging.
California Institute of Technology, January 22, 2002: Aging mutants
in C. elegans reveal trade-offs between life extension and reduced fitness;
are there human applications?
Oak Ridge National Laboratory, Oak Ridge, TN, Feb. 25, 2002: Identification
of life extension genes and relevance to humans and mice.
Institute of Molecular Biology and Biotechnology, Foundation for Research and
Technology, Heraklion, Crete, Greece, May 23, 2002: Increased resistance
to environmental stressors and diseases of aging: common-ground among all gerontogenes.
Department of Nutrition, University of Tennessee, Oct. 18, 2002: Playing
the gene game to understand aging.
Annual Retreat of the Tennessee Mouse Genetics Consortium, Nashville, TN, Jan.
16, 2003: Stress resistance as a screenable trait for identifying mouse gerontogenes.
Department of Integrative Physiology, University of Colorado at Boulder, Dec.
4, 2003 "Life extension mutants in C. elegans."
Case Western Reserve, Dec. 10, 2003, "Programmed aging in the nematode
Caenorhabditis elegans? Environmental stress targets a daf-16 dependent
pathway."
Samuel Lunenfeld Research Institute, March 31, 2004, "Environmental stress
targets a daf-16 dependent pathway and other alternative interpretations for
programmed aging in the nematode Caenorhabditis elegans."
Department of Experimental Medicine and Biochemical Sciences, University of
Rome, "Tor Vergata", Rome, Italy, "Tor Vergata, May 4, 2004,
"Genes, environment and chance specify the life span and aging".
Department of Nematology, Wageningen University, Wageningen, The Netherlands,
December 14, 2004, "Genetic, environmental and chance determination of
the life span and aging".
Laboratory of Experimental Gerontology, Gerontology Research Center, National
Institutes on Aging, Baltimore MD., April 19, 2005, "Genetic, environmental
and chance determination of the life span and aging".
Institute for Biomedical Aging Research of the Austrian Academy of Sciences, July 10-11, 2005, Innsbruck, Austria: “Genes, environment and chance determine longevity.”
Salzburg University, Department of Genetics, July 11-12, 2005, Salzburg, Austria: “Genes, environment and chance determine longevity.”
Karl Franzens University, Department of Molecular Biology, July 13-14, 2005, Graz, Austria: “Genes, environment and chance determine longevity.”
Washington University School of Medicine, Department of Molecular Biology & Pharmacology, November7, 2005, St. Louis, Missouri: “Genes, Environment and Chance Determine Longevity.”
University of Alabama, Birmingham Center for Aging, Dec 2, 2005, Birmingham, Alabama. 2005 Annual Hayflick Lecture, honoring contributions to the biology of aging field. “Genes, environment and chance determine longevity.”
University of Arkansas, Department of Biochemistry and Molecular Biology, Dec. 14, 2005, Little Rock, Arkansas: “Genes, Environment and Chance Coordinately Specify Life Span and Aging.”
Austin, TX, March 23, 2006 "Roles of Genes Environment and Chance in Determining Life Span."
Mayo Clinic, Rochester, MN, May 26, 2006 "Genes, Environment, and Chance All Play a Role in Determining Individual Life Span: How Much of Each?"
Mayo Clinic, Rochester, MN, October 4, 2006. “Life Extension Mutants in C. elegans”
Barshop Institute, Univeristy of Texas Health Sciences Center San Antonio, March 7, 2007, San Antonio, TX “How Genes, Environment and Chance Work Together to Determine Life Span”.
Boulder, CO June 11-13, 2007. Biodemography ~ University of Colorado Population Center Summer Short Course “The Genetics of Longevity”.
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SOLICITED MANUSCRIPTS:
- Johnson, T. E., 1997 The Identification of Gerontogenes in the Nematode
Caenorhabditis Elegans and their Involvement in Resistance to Stress
1997
- Special Report to the U.S. Congress on Alcohol and Health, January, 1998.
EDITORIALS:
- Johnson, T. E., 1988 Thoughts on the selection of longer-lived rodents.
Growth, Develop., Aging 52: 207-209.
- Johnson, T. E., 1999 Introduction to the special issue on "Genetics
and Model Systems". Neurobiol. Aging 20: 469-470.
- Allison, T. E., Miller, R. A., Austad, S. N., Bouchard, C., Leibel, R.,
Klebanov, S., Johnson, T. E., and Harrison, D. E., 2001 Genetic variability
in responses to caloric restriction in animals and in regulation of metabolism
and obesity in humans. J. Gerontol: Biol. Sci. 56A: 55-65.
- Cypser, J. and Johnson. T. E., 2001 Hormesis extends the correlation between
stress resistance and life span in long-lived mutants of Caenorhabditis
elegans. Human and Exp. Toxicol., 20:295-296; 319-320.
- Johnson. T. E., 2001 SAGE thoughts on aging. Commentary on "Changes
in gene expression associated with developmental arrest and longevity in C.
elegans" Gen. Res., 8:1323-1324.
- Johnson. T. E., 2002 Commentary on "How many genes influence aging?"
Mech. Aging Develop, 123:77-78
- Olshansky, S. J., et al. (including myself and 39 others) "Position
statement on anti-aging medicine." Scientific American, 286:92-5
- Johnson, T. E., Martin, G.M. and Smith, J.R., 2003 A forum for commentaries
on recent publications. J. Gerontol: Biol. Sci. 58A: 579-580
- .Houthoofd, K., Braeckman, B. P., Johnson, T. E., Vanfleteren, J.
R., 2004 Extending life-span in C. elegans. Science. 305:1238-1239
- Johnson, T. E. 2005 A salutation from the US. Exper. Gerontol., 40:
5-6.
- Crow, J.F.,and Johnson, T.E., 2005 Research on environmental effects in genetic studies of aging: comments. J. Gerontol.: B Psychol. Sci. Soc. Sci. 60 Spec No 1:7-11.
- Ventura, N., Rea, S. L., Henderson, S. T., Condo, I., Testi, R., and Johnson, T. E. 2006 C. elegans as a model for Friedreich Ataxia. FASEB J. 20:1029-1030.
- Johnson, T. E. 2006 Description of the 2005 Meeting of the Special Interest Group on Societal Implications of Anti-Aging Research at the Gerontological Society of America. Rejuvenation Res. 9:431-432.
- Johnson, T.E. 2006 For the special issue: The nematode Caenorhabditis elegans in aging research. Exp. Gerontol. 41:887-889.
- 15. Grubeck-Loebenstein, B., and Johnson, T. 2006 Introduction to Annual Reviews in Biogerontology. Exp. Gerontol. 41:1207.
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BOOK REVIEWS:
- Johnson, T. E., 1991 The Evolutionary Biology of Aging, by Michael
R. Rose. Am. J. Hum. Genet. 49:469-470.
- 2. Johnson, T. E., 1991 A Hitchhikers Guide to Senescence: Longevity,
Senescence, and the Genome, by Caleb E. Finch. Cell 68:183-184.
- Johnson, T. E., 1995 How and Why We Age, by Leonard Hayflick. Quarterly
Review of Biology 70:331-332.
- Johnson, T. E., 2001 Following the Lead of the Long-Lived Mutants.
The Molecular Genetics of Aging, by Siegfried Hekimi. American Scientist,
89: 84-85.
- Johnson, T. E., 2004 The Start Of Anti-Aging Medicine? Merchants of Immortality
Chasing the Dream of Human Life Extension, by Stephen S. Hall and Ageless
Quest, One Scientist's Search for Genes that Prolong Youth by Lenny Guarente.
The Gerontologist, 44: 270-270.
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BOOKS EDITED:
- Mitchell, D. H. and Johnson, T. E. (Eds.), Invertebrate Models in Aging
Research. CRC, Boca Raton, FL, 1984.
- Finch, C. E. and Johnson, T. E. (Eds.), Molecular Biology of Aging,
UCLA Symposia on Molecular and Cellular Biology, Vol. 123, Alan R. Liss, NY,
1990.
- Johnson, T. E. Editor for Genetics: Handbook of the Biology of Aging,
Fourth Edition. Schneider, E. L. and Rowe, J. W. (Eds.), Academic Press, NY,
1996.
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BOOKS AUTHORED:
- Committee on Chemical Toxicity and Aging, (Johnson, T. E. Member), Aging
in Today's Environment. 1987 National Research Council, National Academy
of Sciences Press.
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Papers Presented at Professional Conferences but not Published:
- Johnson, T. E. and Shook, D. R. Theoretical knowledge for demography to
be gained from quantitative trait locus analysis. A presentation at the Biodemography
of Aging Expert Meeting. Beckman Center, National Academy of Sciences, Irvine,
CA, October 27, 1995.
- Johnson, T. E. Quantitative trait loci for alcohol-related behaviors in
non-human mammals. A report to the National Institute on Alcoholism and Alcohol
Abuse in reviewing research priorities in the area of alcohol-related genetics,
Washington D. C. Nov. 3, 1997.
- Johnson, T. E. Animal genetic studies on the etiology of alcoholism. A report
to the National Institute on Alcoholism and Alcohol Abuse prepared in support
of the Tenth Special Report to the U.S. Congress on Alcohol and Health, January,
1998.
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INTERNET PRESENTATIONS:
- Johnson, T. E., Murakami, S., Cypser, J., Link, C., Rikke, B. and Tedesco,
P., Genetic manipulation of longevity in C. elegans through increased
response to stress. Internet World Congress, Dec. 7-16, 1998, http://www.mcmaster.ca/inabis98/index.html.
- Michalski, A. I., Johnson, T. E., Cypser, J. W., Yashin, A. I., Changes
in C. elegans surviving after early life heating. March 1, 2000. http://www.stress-conference.com.
- 1. T. E. Johnson, Subfield History: Caenorhabditis elegans as a System
for Analysis of the Genetics of Aging Science's SAGE KE (28 August 2002),
http://sageke.sciencemag.org/cgi/content/full/sageke;2002/34/re4
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PUBLISHED INTERVIEWS IN SCIENTIFIC JOURNALS:
- An Interview with Tom Johnson, Ph.D. 2000 "Pieces of the Puzzle".
J. Anti-Aging Med. 2:325-329.
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ABSTRACTS :
- Johnson, T. E., 1972 A method for isolating protoperithecia. Neurospora
Newsletter 19:22.
- Johnson, T. E., 1974 Some mutations affecting perithecial and spore pigmentation.
Neurospora Newsletter 22:19-20.
- Johnson, T. E., 1975 Pattern formation in Neurospora crassa perithecial
development: A mosaic analysis. Genetics 80:345-346.
- 4. Johnson, T. E., 1976 Analysis of a perithecial developmental mutant in
Neurospora crassa that is male and female fertile. Genetics 83:36-37.
- Johnson, T. E., 1978 A method for obtaining high specific activity radioactive
extracts from perithecia. Neurospora Newsletter 25:14-15.
- Johnson, T. E., 1979 A search for position effects in Neurospora. Neurospora
Newsletter 26:14
.
- 7. Johnson, T. E., McAfee, M. and Wood, W. B., 1979 The generation of genetic
mosaics. Cold Spring Harbor Symposium on C. elegans, p. 34.
- Johnson, T. E., McCaffrey, G. and Kauffman, D., 1980 Characterization of
worm senescence. C. elegans Newsletter 5:1.
- Johnson, T. E., 1980 Generation of X-linked mosaics. C. elegans Newsletter 5:1.
- Johnson, T. E., McCaffrey, G. and Lashlee, C. H., 1980 Genetic control of
aging in Caenorhabditis elegans. Genetics 95:S51.
- Johnson, T. E., Lashlee, C. H. and McCaffrey, G., 1981 Genetic control of
lifespan. C. elegans Newsletter 6:1.
- Johnson, T. E., Lashlee, C. H. and McCaffrey, G., 1981 Quantitative genetics
of lifespan. Abstracts of the Third International C. elegans Conference,
p.53.
- McCaffrey, G. and Johnson, T.E., 1981 Protein changes during lifespan: 2-D
gel analysis. Abstracts of the Third International C. elegans Conference,
p. 42.
- Johnson, T. E., Lashlee, C. H. and McCaffrey, G., 1981 Quantitative genetics
of lifespan in Caenorhabditis elegans. Genetics 97:S53-S54.
- Johnson, T. E., 1982 Use of recombinant inbred strains in the genetic analysis
of lifespan. C. elegans Newsletter 7(1):64.
- Kline, S. and Johnson, T. E., 1982 Effects of developmental blocks on lifespan.
C. elegans Newsletter 7(1):64.
- McCaffrey, G. and Johnson, T. E., 1982 Absence of protein changes in "old"
worms. C. elegans Newsletter 7(1):66.
- Johnson, T. E. and Robinson, L., 1982 Use of recombinant inbred lines in
the genetic analysis of lifespan in Caenorhabditis elegans. Genetics 100:S52.
- Johnson, T. E. and Robinson, L. A., 1982 Genetic analysis of lifespan in
the nematode, Caenorhabditis elegans. Behav. Genet. 12:588-589.
- Johnson, T. E., 1982 Genetic analysis of long-lived strains of the nematode,
C. elegans. The Gerontologist 22:185.
- Johnson, T. E., 1983 The use of recombinant inbred lines of the nematode,
Caenorhabditis elegans, in the genetic analysis of lifespan, development
and behavior. Genetics 104:S37-S38.
- Johnson, T. E., Robinson L. and Cuccaro, P. M., 1983 Genetics of long-lived
variants of C. elegans. Abstracts of the Fourth International C.
elegans Conference, p. 50.
- Johnson, T. E., 1983 Use of recombinant inbred lines of the nematode, Caenorhabditis
elegans, in quantitative analysis of behavior, development, and senescence.
Behav. Genet. 13:539.
- Cuccaro, P. and Johnson T. E., 1983 Reversible blocks of aging and development.
C. elegans Newsletter 8.1:15-16.
- Mitchell, D. H. and Johnson, T. E., 1984 Development and senescence are
reversibly arrested by transient starvation in the nematode, Caenorhabditis
elegans. The Gerontologist 24:228.
- Johnson, T. E. and Mitchell, D. H., 1984 Aging is arrested when development
is arrested in the nematode, Caenorhabditis elegans. Genetics
107:S53.
- Friedman, D. B. and Johnson, T. E., 1984 Genetic analysis of a long life-span
mutant strain. C. elegans Newsletter 8.3:12-13.
- Keller, M. L. and Johnson, T. E., 1984 Movement behavior as a predictor
of life-span. C. elegans Newsletter 8.3:14-15.
- Simpson, V. J. and Johnson, T. E., 1984 No 5'methyl-cytosine in worm DNA.
C. elegans Newsletter 8.3:16.
- Friedman, D. and Johnson, T., 1985 Genetic analysis of a long-lived mutant.
Abstracts of the Fifth International C. elegans Conference, p. 45.
- Johnson, T., 1985 Life-spans of induced mutants. Abstracts of the Fifth
International C. elegans Conference, p. 58.
- Hartman, P., Simpson, V. and Johnson, T., 1985 Life-span of recombinant
inbreds do not correlate with sensitivities to three DNA-damaging agents.
Abstracts of the Fifth International C. elegans Conference, p. 68.
- Etebar, S. and Johnson, T., 1985 Effects of ionizing irradiation on life-span.
Abstracts of the Fifth International C. elegans Conference, p. 39.
- Simpson, V., Johnson, T. and Klass, M., 1985 Absence of 5-methylcytosine
in DNA at any age. Abstracts of the Fifth International C. elegans
Conference, p. 133.
- Johnson, T. E. and the Nematode Aging Group, 1985 Life-spans of induced
mutants. Abstracts of the 1st International Meeting on Biomedical Gerontology,
AGE 8:91.
- Johnson, T. E., Friedman, D. B., Fitzpatrick, P. A., Conley, W. L. and Bryant,
M. L., 1986 Recessive mutations in a single gene confer life-span extensions
of 70% in Caenorhabditis elegans. Genetics 113:S30.
- Johnson, T. E., Friedman, D. B., Fitzpatrick, P. A. and Conley, W. L. 1986
Characterization of genetic stocks which prolong life. The Gerontologist
26:75A.
- Johnson, T., Conley, B. and Bryant, M., 1986 Developmental effects of loci
lengthening life-span. C. elegans Newsletter 9.1:98.
- Friedman, D. and Johnson, T., 1986 Further genetic analysis of a long-life
mutant strain. C. elegans Newsletter 9.1:99.
- Fitzpatrick, P. and Johnson, T., 1986 Analysis of the age-1 locus by three-factor
crosses. C. elegans Newsletter 9.1:100.
- Johnson, T., Wagner, J. and Nguyen, H., 1986 Isolating long-lived mutants.
C. elegans Newsletter 9.1:102.
- Johnson, T. E., Friedman, D. B., Fitzpatrick, P. A. and Conley, W. L., 1986
Mutant genes that extend life span. Brookhaven Symposium, Number 34, Abstracts,
p.10.
- Friedman, D. B. and Johnson, T. E., 1986 Mutations specifying increased
mean and maximum life-span in the nematode, Caenorhabditis elegans.
Ann. Meetings of Soc. for Develop. Biol.
- Cruzen, M. and Johnson, T., 1987 Lysosomal enzyme activity as a biomarker
of aging using long-lived lines of Caenorhabditis elegans. Abstracts
of the Sixth International C. elegans Conference, p. 155.
- Friedman, F. and Johnson, T., 1987 Genetic analysis of age-1, a gene which
increases mean and maximum life span in C. elegans. Abstracts of the
Sixth International C. elegans Conference, p. 130.
- Fitzpatrick, P. and Johnson, T., 1987 Attempts to separate long life and
reduced fertility using four factor crosses. Abstracts of the Sixth International
C. elegans Conference, p. 145.
- Shoemaker, J., Friedman, D., Fitzpatrick, P. and Johnson, T. , 1987 Deficiency
mapping of the age-1 locus in Caenorhabditis elegans. Abstracts of
the Sixth International C. elegans Conference, p. 43.
- Foltz, N. and Johnson, T., 1987 Life span and self-fertility polygenes in
C. elegans. Abstracts of the Sixth International C. elegans
Conference, p. 143.
- Johnson, T. E., 1987 Recombinant inbred lines can be used to conveniently
map cloned DNA fragments based solely on strain distribution patterns.
C. elegans Newsletter 10.1:15.
- Shoemaker, J. E. and Johnson, T., 1987 Progress in cloning the age-1
gene. C. elegans Newsletter 10.1:16.
- Cruzen, M. and Johnson, T., 1987 Preparation and maintenance of age-synchronous
mass cultures. C. elegans Newsletter 10.1:141.
- Johnson, T. E., 1988 A mutation in a single gene produces a 70% increase
in the life span of the round worm Caenorhabditis elegans. Abstracts
of the International Symposium on the Biology of Aging, pp. 22-26.
- Foltz, N. and Johnson, T., 1988 Long life and low fertility: mating experiments
with mutants and wild-type hermaphrodites. Abstracts of the 1988 C. elegans
meetings at Arrowhead.
- Shoemaker, J., Fitzpatrick, P. and Johnson, T., 1988 Strange happenings
at the age-1 locus. Abstracts of the 1988 C. elegans meetings
at Arrowhead.
- Johnson, T., 1988 Genetic modulation of the aging processes. 39th Annual
Meeting of the Tissue Culture Association.
- Johnson, T., 1988 A developmental genetic approach to the analysis of aging
processes. Biomedical Advances in Aging '88, Abstracts.
- Foltz, N., Johnson, T. and Shoemaker, J. E., 1988 Long life and low fertility:
mating effects on life span. C. elegans Newsletter 10.2:37.
- Johnson, T. E., 1988 How genetics can be used to infer causality among aging
related events. 41st Annual Meeting of the Gerontological Society of America.
- Johnson, T. E., 1988 Mutant genes that extend life span. The Gerontologist
28:298A.
- Hutchinson, E. W., Tedesco, P. M., Link, C. D. and Johnson, T. E., 1989
Cloning genes for life-extension in Caenorhabditis elegans. J. Cell.
Biochem 13C:140.
- Hutchinson, E. W., Tedesco, P. and Johnson, T. E., 1989 Molecular and genetic
localization of age-1: one gene and its nature. Abstracts of the Seventh International
Meeting on C. elegans, p.130.
- Fabian, T. J. and Johnson, T. E., 1989 Age-dependent transcription. Abstracts
of the Seventh International Meeting on C. elegans, p. 73.
- Johnson, T. E., 1989 Molecular genetic analysis of processes limiting life.
Third International Congress of Biomedical Gerontology.
- Johnson, T. E., 1989 Genetic analysis of life span: Whence and Where. The
Gerontologist 29:64A.
- Johnson, T. E., 1989 Aging: Is it all in your genes? 90 Minutes, Alumni
lecture series at University of Colorado.
- Johnson, T. E., 1990 Aging genes in worms. 1990 American Association for
the Advancement of Science Annual Meeting Abstracts, p. 129.
- Hutchinson, E. W., Tedesco, P. M. and Johnson, T. E., 1990 Antagonistic
pleiotropy in nematode aging: a genetic analysis. Society for Evolutionary
Biology Annual Meeting.
- Johnson, T. E., 1990 Genetic analysis of aging genes in nematodes. Workshop
on the Correlations of Aging and Space Effects on Biosystems (CASEB).
- Johnson, T. E., Tedesco, P. M. and Hutchinson, E. W., 1990 Molecular and
classical genetic analysis of life span in Caenorhabditis elegans. The
Gerontologist 30:251A-252A.
- Brooks, A. and Johnson, T. E., 1990 Fertility in C. elegans. Abstracts of
the 1990 West Coast C. elegans meetings, Seattle, WA.
- Johnson, T. E., Tedesco, P. M. and Hutchinson, E. W., 1990 Cloning a gene
specifying life-span extension. Third Serling Symposium on the Biology of
Aging, Jerusalem, Israel.
- Johnson, T. and Tedesco, P., 1990 Identification of deficiency endpoints
surrounding fer-15 and emb-27. C. elegans Newsletter
11.4:14.
- Hutchinson, E. W. and Johnson, T. E., 1990 age-1 and fer-15
are separate genes. C. elegans Newsletter 11.4:74.
- Fabian, T. and Johnson, T., 1990 Isolation of cDNAs differentially expressed
during the adult life span. C. elegans Newsletter 11.4:13.
- Brooks, A. and Johnson, T., 1990 Effects of deficiencies on hermaphrodite
fertility. C. elegans Newsletter 11.4:73.
- Johnson, T. E., Greenlee, J. T. and Markel, P. D., 1991 QTL mapping of genes
conferring ethanol sensitivity. Alcohol.: Clin. Exp. Res. 15:320.
- Johnson, T. E., 1991 Identifying and cloning genes that limit life span
of Caenorhabditis elegans. 1991 Asia/Oceania Conference on Gerontology,
Yokohama, Japan.
- Brooks, A., Wold, R. and Johnson, T. E., 1991 The interaction between hermaphrodite
fertility and life span. Abstracts of the Eighth International Meeting on
C. elegans.
- Tedesco, P., Hutchinson, E. and Johnson, T., 1991 Deficiency mapping shows
that reduced hermaphrodite self fertility is separable from age-1.
Abstracts of the Eighth International Meeting on C. elegans.
- Fabian, T. J. and Johnson, T., 1991 Isolation and characterization of genes
which are differentially expressed during the adult life span. Abstracts of
the Eighth International Meeting on C. elegans.
- Hutchinson, E., Lindsay, D. and Johnson, T., 1991 Multi-point mapping of
age-1. Abstracts of the Eighth International Meeting on C. elegans.
- Duhon, S. and Johnson, T., 1991 Movement and pharyngeal pumping as biomarkers
of longevity. Abstracts of the Eighth International Meeting on C. elegans.
- Brooks, A., Wold, R. and Johnson, T. E., 1991 The interaction between hermaphrodite
fertility and life span in C. elegans. The Gerontologist 31
(special edition II):77.
- Hutchinson, E. W., Lindsay, D. and Johnson, T. E., 1991 Multi-point mapping
of age-1. The Gerontologist 31 (special edition II):180.
- Brooks, A., Wold, R. and Johnson, T. E., 1991 The interaction between hermaphrodite
fertility and life span in C. elegans. AGE 14:139.
- Johnson, T., Fabian, T., Tedesco, P. and Hutchinson, T., 1991 Molecular
genetic approaches to the analysis of aging in Caenorhabditis elegans.
AGE 14:135-136.
- Fabian, T. J. and Johnson, T. E., 1991 Differential gene expression during
the adult life span of C. elegans. AGE 14:143.
- Duhon, S. and Johnson, T., 1991 Movement and pharyngeal pumping as biomarkers
of longevity in Caenorhabditis elegans. AGE 14:140.
- Johnson, T. E., Tedesco, P. M., Hutchinson, E. W., Brooks, A. and Lithgow,
G. J., 1992 Identification and cloning of gerontogenes in Caenorhabditis
elegans. Abstracts of the annual meeting of the American Association for
the Advancement of Science, Chicago.
- Jensen, A. and Johnson T., 1992 Paraquat resistance maps near the age-1
locus in multipoint mapping in Age recombinant strains. C. elegans
Newsletter 12.2:101.
- Tedesco, P. and Johnson, T., 1992 Integrated transgenic lines rescue fertility
in Age strains. C. elegans. Newsletter 12.2:39.
- Markel, P. D. and Johnson, T. E., 1992 Detection of QTLs regulating ethanol
sensitivity using STS mapping. Alcohol.: Clin. Exp. Res. 16:373.
- Fabian, T. and Johnson, T., 1992 Differential gene expression in the adult
life span of C. elegans. Abstracts of the 1992 Cold Spring Harbor Meeting
on the Molecular Biology of Aging p. 55.
- Lithgow, G. J., Tedesco, P. M., Hutchinson, E. W., Melov, S. and Johnson,
T. E., 1992 Cloning of the C. elegans gerontogene, age-1. Abstracts
of the 1992 Cold Spring Harbor Meeting on the Molecular Biology of Aging,
p. 16.
- Johnson, T. E., Hutchinson, E. W., Tedesco, P., Brooks, A., Fabian, T. J.,
Duhon, S., Lithgow, G. J. and Melov, S. L., 1992 Genetic approaches to the
dissection of aging processes of Caenorhabditis elegans. Abstracts
of the 1992 Cold Spring Harbor Meeting on the Molecular Biology of Aging,
p. 63.
- Lithgow, G. J., Johnson, T. E., Tedesco, P. M., Brooks, A., Fabian, T. J.,
Duhon, S. A. and Melov, S. L., 1992 Genetic approaches to the dissection of
aging processes of Caenorhabditis elegans. Behav. Genet. 22:732.
- Johnson, T. E., DeFries, J. C., Jensen, A. K. and Markel, P. D. , 1992 Mapping
quantitative trait loci for behavioral traits in the mouse. Behav. Genet.
22:728.
- Duhon, S. A. and Johnson, T. E., 1992 Movement and pharyngeal pumping as
biomarkers of aging in Caenorhabditis elegans. Behav. Genet. 22:719.
- Markel, P. D. and Johnson, T. E., 1992 Repeatability of ethanol induced
sleep time in mice. Behav. Genet. 22:734.
- Fabian, T. J. and Johnson, T. E., 1992 Age-dependent expression during the
adult life span of Caenorhabditis elegans. Behav. Genet. 22:720.
- Brooks, A. and Johnson, T. E., 1992 Mapping quantitative trait loci for
life span and self-fertility. Behav. Genet. 22:712.
- Brooks, A. and Johnson, T. and Hutchinson, T., 1992 Mapping quantitative
trait loci for life span and self-fertility. C. elegans Newsletter
12.3:114-115.
- Johnson, T., Lithgow, G., Tedesco, P., Brooks, A., Fabian, T., Duhon, S.,
Jensen, A. and Melov, S., 1992 Genetic dissection of aging processes in Caenorhabditis
elegans. Fourth Serling Symposium on the Biology of Aging.
- Nelson, J. F., Karelus, K., Felicio, L. S. and Johnson, T. E., 1992 Reproductive
lifespan differs among genotypes and is correlated with longevity in mice.
The Gerontologist 32 (special edition II):218.
- Brooks, A. and Johnson, T. E., 1992 Mapping quantitative trait loci for
life span and self-fertility in the nematode Caenorhabditis elegans.
The Gerontologist 32 (special edition II):121-122.
- Lithgow, G. J., Tedesco, P. M., Hutchinson, E. W., Melov, S. and Johnson,
T. E., 1992 Cloning of a life-span-limiting gene from C. elegans. Molecular
Mechanisms of Aging Symposium.
- Melov, S., Jensen, A. and Johnson, T. E., 1992 Examination of the effects
of paraquat on long lived strains of C. elegans. Molecular Mechanisms
of Aging Symposium.
- Fabian, T. J. and Johnson, T. E., 1993 Isolation of genes that are differentially
expressed during aging in C. elegans. Molecular Biology of Aging, Keystone
Symposium, J. Cell Biochem. Supp. 17D:159.
- Lithgow, G. J., Tedesco, P. M., Hutchinson, E. W., Melov, S. L., Jensen,
A., Duhon, S. and Johnson, T. E., 1993 Molecular genetics of C. elegans
life span. Molecular Biology of Aging, Keystone Symposium, J. Cell Biochem.
Supp. 17D:144.
- Melov, S. L. and Johnson, T. E., 1993 Mitochondrial deletions with age in
the nematode C. elegans. Meeting on Molecular Biology of Aging, Keystone
Symposium, J. Cell Biochem. Supp. 17D:166.
- Duhon, S.A. and Johnson, T.E., 1993 Detection of new long-lived mutants
in Caenorhabditis elegans. The Gerontologist 33:96.
- Johnson, T. E., Cassel, C., Cole, T., Binstock, R. and Hackler, C., 1993
Adding life to years: Realty, implications, societal and ethical considerations.
The Gerontologist 33:95-96.
- Johnson, T. E., 1993 What is the role of genetics in longevity? The Gerontologist
33:202-203.
- Duhon, S. and Johnson, T., 1993 Movement as index of vitality. Abstracts
of the Ninth International Meeting on C. elegans, p. 108.
- Fabian, T., Gehle, V. and Johnson, T., 1993 Isolation of genes having differential
expression during aging in C. elegans. Abstracts of the Ninth International
Meeting on C. elegans, p. 125.
- Lithgow, G., Tedesco, P., Hutchinson, E. and Johnson, T., 1993 Toward cloning
of the C. elegans gerontogene, age-1. Abstracts of the Ninth
International Meeting on C. elegans, p. 278.
- Lithgow, G., White, T., Melov, S., Jensen, A. and Johnson, T., 1993 Response
of long-lived mutant strains to stress. Abstracts of the Ninth International
Meeting on C. elegans, p. 279.
- Melov, S. and Johnson, T., 1993 Increase in mitochondrial deletions (dmtDNA)
with age in the nematode C. elegans. Abstracts of the Ninth International
Meeting on C. elegans, p. 309.
- Markel, P., Beeson, M., Gordon, L., and Johnson, T., 1993 Mapping of QTLs
regulating ethanol-induced anesthesia. Psyc. Genet. 3:141.
- Lithgow, G., Tedesco, P., Hutchinson, T., White, T., Melov, S. and Johnson,
T., 1993 Molecular genetics of aging in C. elegans. Abstracts of Symposium
on the Cellular and Molecular Aspects of Aging.
- Johnson, T. E., Markel, P. D., Fulker, D. W., DeFries, J. C. and Melov,
S., 1994 Mapping QTLs for ethanol-induced anesthesia in LSXSS recombinant
inbred and F2 mice. Abstracts of Seventh Congress of the International Society
for Biomedical Research on Alcoholism. Alcohol.: Clin. Exp. Res. 18:6A.
- Fulker, D. W., Markel, P. D., DeFries, J. C., Corley, R. P. and Johnson,
T. E., 1994 Use of interval mapping to localize quantitative trait loci in
recombinant inbred strains. Alcohol.: Clin. Exp. Res. 18:452.
- Markel, P. D., Beeson, M. A., Gordon, L., DeFries, J. C., Melov, S. and
Johnson, T. E., 1994 Mapping QTLs influencing ethanol-induced anesthesia in
LS and SS mice. Alcohol.: Clin. Exp. Res. 18:452.
- Simpson, V. J., Keller, A. L. and Johnson, T. E., 1994 An analysis of LSXSS
sleep time response to the anesthetic inhalational agents isoflurane and enflurane.
Alcohol.: Clin. Exp. Res. 18:485.
- Hinerfeld, D., Lithgow, G. J. and Johnson, T. E., 1994 Decrease in thermotolerance
with age in long-lived mutants of C. elegans. The Gerontologist
34:18, 129, 364.
- Johnson, T. E., Kenyon, C., Larsen, P., Shmookler-Reis, R. J. and Lithgow,
G. J., 1994 The nematode C. elegans, a model for the genetic analysis
of aging processes. The Gerontologist 34:317.
- Johnson, T. E., 1994 Genetic influences on longevity and aging rate. The
Gerontologist 34:292.
- Lithgow, G. J., White, T., Hinerfeld, D., Duhon, S. A. and Johnson, T.
E., 1994 Thermotolerance exhibited by a long-lived C. elegans mutant.
Cold Spring Harbor Laboratory Meeting on the Biology of Heat Shock Proteins
and Molecular Chaperones, p. 173.
- Johnson, T. E., 1994 Testing biological theories of aging: Fact versus theory.
The Gerontologist 34:114.
- Johnson, T. E., Simpson, V. J., Markel, P. D., Bennett, B., Beeson, M. A.
and Gordon, L., 1994 Mapping quantitative trait loci influencing general anesthesia
sensitivity in LS and SS mice. Mouse Genome Conference, London.
- Johnson, T. E., Lithgow, G. J., Murakami, S., Tedesco, P. M., Duhon, S.
A., Shook, D. R., White, T. M. and Melov, S., 1994 Dissection of the physiology
underlying long-lived mutants of C. elegans.
- Rikke, B. A., Bennett, B., Markel, P. D., Simpson, V. J., Johnson, D. K.,
Montoliu, L. and Johnson, T. E., 1995 Identification of a QTL for ethanol
and general anesthetic sensitivity near the albino locus. Alcohol.: Clin.
Exp. Res. 19:47A.
- Bennett, B., Markel, P. D., Beeson, M. A., Gordon, L. and Johnson, T. E.,
1995 Mapping QTLs influencing ethanol-induced anesthesia in LS and SS mice:
F2 confirmation. Alcohol.: Clin. Exp. Res. 19:47A.
- Simpson, V. J., Keller, A., Bennett, B. and Johnson, T. E., 1995 Mapping
QTLs influencing general anesthetic sensitivity in LS and SS mice. Alcohol.:
Clin. Exp. Res. 19:47A.
- Cherny, S. S., Corley, R. P., Fulker, D. W., DeFries, J. C., Goodman, D.
W., Markel, P. D. and Johnson, T. E., 1995 Regression approaches to QTL analyses
in selected F2 samples. Alcohol.: Clin. Exp. Res. 19:48A.
- Lithgow, G. J., White, T. M. and Johnson, T. E., 1995 age-1 thermotolerance
may be associated with hsp16 accumulation. C. elegans Newsletter, p.
81.
- Lithgow, G. J., White, T. M. and Johnson, T. E., 1995 Stress response and
lifespan. C. elegans Newsletter, p. 82.
- Murakami, S. and Johnson, T. E., 1995 A common phenotype of longer life
mutants in C. elegans. C. elegans Newsletter, p. 83.
- Shook, D. R., Brooks, A. and Johnson, T. E., 1995 QTL mapping of life history
traits in C. elegans. Behav. Genet. 25:300.
- Hanebuth, E., Johnson, T. E., Fulker, D. W. and Wehner, J. M., 1995 Quantitative
trait loci for bicuculline seizure susceptibility in long-sleep and short-sleep
recombinant inbred strains of mice. Behav. Genet. 25:269.
- Christensen, S. C., Johnson, T. E., Markel, P. D., Fulker, D. W., Corley,
R. P., Collins, A. C. and Wehner, J. M., 1995 Quantitative trait locus analyses
of sleep-times induced by several sedative-hypnotic drugs of abuse in LSXSS
recombinant inbred strains of mice. Behav. Genet. 25:260.
- Duhon, S. A. and Johnson, T. E., 1995 The isolation and characterization
of age mutants. Abstracts of the Tenth International Meeting on C. elegans,
p. 194.
- Murakami, S. and Johnson, T. E., 1995 Longer-life mutants share a common
mechanism conferring stress resistance in C. elegans. Abstracts of
the Tenth International Meeting on C. elegans, p. 390.
- Shook, D. R., Brooks, A. and Johnson, T. E., 1995 QTL mapping of life history
traits in C. elegans. Abstracts of the Tenth International Meeting
on C. elegans, p. 468.
- Simpson, V. J., Keller, A., Rikke, B., Bennett, B., Johnson, D. and Johnson,
T. E., 1995 Mapping QTLs influencing general anesthetic sensitivity in LS
and SS mice. The Biology and Genetics of Complex Mammalian Traits, Bar Harbor,
ME.
- Johnson, T. E., Bennett, B., Rikke, B., Beeson, M. and Gordon, L., 1995
Mapping QTLs for ethanol sensitivity in LS and SS mice. The Biology and Genetics
of Complex Mammalian Traits, Bar Harbor, ME.
- Christensen, S. C., Johnson, T. E., Markel, P. D., Fulker, D. W., Corley,
R. P., Collins, A. C. and Wehner, J. M., 1995 Quantitative trait locus analyses
of sleep-times induced by several sedative-hypnotics in LSXSS recombinant
inbred strains of mice. Alcohol.: Clin. Exp. Res. 19:47A.
- Erwin, V. G., Radcliffe, R. A, Jones, B. C., Johnson, T. E. and Fulker,
D. W., 1995 Genetic correlations and quantitative trait loci for ethanol actions
and neurotensin levels in brain regions from LS X SS RI strains of mice. Alcohol.:
Clin. Exp. Res. 19:47A.
- Erwin, V. G., Jones, B. C., Fulker, D. W. and Johnson, T. E., 1995 Quantitative
trait loci for ethanol actions and neurotensin receptors in brain regions
from LS X SS RI strains of mice. Alcohol.: Clin. Exp. Res. 19:47A.
- Johnson, T. E., Bennett, B., Rikke, B., Simpson, V. J., Beeson, M. and
Gordon, L., 1995 From character to clone: Mapping the mouse genes responsible
for sensitivity to ethanol. Obesity Research 3:316s.
- Smith, D. W. E., Carues, B. A., Olshansky, S. J., Grahn, D., Johnson, T.
E. and Vaupel, J. W., 1995 New perspectives on longevity. The Gerontologist
35:278.
- Johnson, T. E., 1995 Tutorial on models for the study of aging. The
Gerontologist 35:125.
- Duhon, S. A. and Johnson, T. E., 1995 Isolation and characterization of
age mutants. C. elegans Newsletter, 14:101.
- Murakami, S., Tedesco, P. M., Lithgow, G. J., Hutchinson, E. W. and Johnson,
T. E., 1995 Mapping of age-1 and daf-23. C. elegans Newsletter,
14:100.
- Johnson, T. E., Markel, P. D., Bennett, B., Hume, G., Rikke, B., Beeson,
M. and Gordon, L., 1996 Mapping QTLs for ethanol sensitivity in F2 from ILS
by ISS mice. Alcohol.: Clin. Exp. Res. 20:26A.
- Johnson, T. E., Murakami, S., Tedesco, P. M., Duhon, S. A., Shook, D. R.
and Lithgow, G. J., 1996 Identifying and cloning longevity-determining genes
in the nematode C. elegans. Colloques Médécine et Recherche,
Fondation IPSEN.
- Simpson, V. J., Keller, A. L., Rikke, B. and Johnson, T. E., 1996 Testing
the role of the Tyr gene in propofol/ethanol neurosensitivity in LS/SS
mice. Alcohol.: Clin. Exp. Res. 20:24A.
- Simpson, V. J., Costello, J., Rikke, B., Corley, R. and Johnson, T. E.,
1996 Mapping a major QTL for propofol neurosensitivity in F2 mice from an
LS by SS cross. Anesthesiology.
- Shook, D. R., Hinerfeld, D. A. and Johnson, T. E., 1996 QTLs for life history
traits in Caenorhabditis elegans. The Gerontologist 36:203.
- Shook, D. R., Brooks, A. and Johnson, T. E., 1995 Mapping life history QTLs
using C. elegans recombinant inbred strains: a model system for detecting
antagonistic pleiotropy and epistasis at the single gene level. Evolutionary
Biology Meetings, Poster Abstracts.
- Rikke, B. A., Johnson, D. A. and Johnson, T. E., 1996 Microsatellite-based
physical and genetic maps of the murine albino deletion complex to support
the positional cloning of developmental genes. Cold Spring Harbor Mouse Molecular
Genetics Meeting.
- Murakami, S., Tedesco, P. M., Dames, S. and Johnson, T. E., 1996 A geronto-
pathway confers stress resistance. The Gerontologist 36:204.
- Bennett, B., Beeson, M., Gordon, L. and Johnson, T. E., 1997 Identifying
the genes underlying the QTLs for ethanol sensitivity in LS and SS mice: Confirmation
of QTLs using marker-assisted selection. Alcohol.: Clin. Exp. Res.,
21: 18A.
- Johnson, T. E., Bennett, B., Beeson, M. and Gordon, L., 1997 Identifying
the genes underlying the QTLs for ethanol sensitivity in LS and SS mice: Marker-assisted
congenic construction. Alcohol.: Clin. Exp. Res., 21: 18A.
- Erwin, V. G., Costello, J. and Johnson, T. E., 1997 Development of congenic
C57BL strains with DBA alleles for ethanol avoidance; Confirmation of QTL
regulating ethanol consumption. Alcohol.: Clin. Exp. Res., 21:
18A.
- Johnson, T. E., Murakami, S., Link, C. and Lithgow, G., 1997 Genetic determination
of aging in C. elegans: The role of the stress response system. Fourth
North-South Human Genome Conference, UNESCO.
- Cypser, J. R. and Johnson, T. E., 1997 Stress resistance and life span in
selected strains. 11th International C. elegans Meeting, p. 600.
- Dames, S. A. and Johnson, T. E., 1997 Mortality kinetics of large populations
of C. elegans. 11th International C. elegans Meeting, p. 598.
- Murakami, S. and Johnson, T. E., 1997 Anti-aging kinase receptor. 11th International
C. elegans Meeting, p. 338.
- Murakami, S., Kliminskaya, M. and Johnson, T. E., 1997 daf-23 may
not be age-1. 11th International C. elegans Meeting, p. 337.
- Johnson, T. E., Murakami, S., Link, C., Rikke, B., Dames, S. and Cypser,
J. 1997 Gerontogenes leading to increased health and longevity in nematodes.
Bat-Sheva Seminar on Cellular, Molecular and Genetic Aspects of Aging and
Longevity, December 7-12, 1997, Israel
- Johnson, T. E., Murakami, S., Link, C., Rikke, B. and Cypser, J. 1998 Increased
resistance to stress is a marker for gerontogenes leading to increased health
and longevity in nematodes. Alfred Benzon Symposium No. 44, Copenhagen, Denmark.
- Shen, E.H., Moir, P.T., and Johnson, T.E., 1998 Effects of ketamine on locomotor
activity and loss of righting reflex in LS and SS mice. Alcohol.: Clin.
Exp. Res., 22: 101A.
- Johnson,T.E., and Bennett, B., 1998 Phenotypic confirmation of QTLs for
ethanol sleep time using congenic strains of mice. Alcohol.: Clin. Exp.
Res., 22: 101A.
- Whatley, V. J., Erwin, V. G., and Johnson, T. E., 1998 Identification of
QTLs responsible for ethanol preference in the development of congenic C57BL/6
strains with DBA/2 donor alleles. Alcohol.: Clin. Exp. Res., 22:
101A.
- Shimizum, M., Tsuboyama, T., Matsushita M., Higuchi, K., Hosokaza, M., Bennett,
B., Johnson, T.E., and Nakamura, T., 1998 Identification of Quantitative Trait
Loci that Control Low PFAK Bone Mass Using a Spontaneously Osteoporotic Mouse
Strain, Samp6. 3rd Comined Meeting of the Orthopaedic Research Societies,
September 28-30, 1998, Japan.
- Johnson, T. E., 1998 Life extension as resistance to stress: toward a molecular
description. NHMCC Bio/Technology Conferences: Frontiers in Aging research
and Age-Related Diseases, Oct. 5-7, San Diego, CA. (Meeting cancelled).
- Johnson, T. E., Murakami, S., Link, C., Tedesco, P., Rikke, B. and Cypser,
J., 1999 Genetic and environmental manipulation of longevity in C. elegans.
Keystone Symposia: Aging: Genetic and Environmental Influences on Life Span,
Feb. 2-7, Durango, CO.
- Cypser, J. R., Johnson, T. E., 1999 Hormesis, gerontogenes and daf-16.
Keystone Symposia: Aging: Genetic and Environmental Influences on Life Span,
Feb. 2-7, Durango, CO.
- Murakami, S., Kliminskaya, M. and Johnson, T. E., 1999 Positive regulation
of longevity and resistance to environmental stress by TKR-1 receptor tyrosine
kinase in C. elegans. Keystone Symposia: Aging: Genetic and Environmental
Influences on Life Span, Feb. 2-7, Durango, CO.
- Johnson, T. E., Murakami, S., Cypser, J., Link, C., Rikke, B. and Tedesco,
P., Genetic manipulation of longevity in C. elegans through increased
response to stress. Internet World Congress, Dec. 7-16, 1998, http://www.mcmaster.ca/inabis98/index.html.
- Johnson,T. E., and Bennett, B., 1999 Phenotypic confirmation of QTLs for
ethanol sleep time using congenic and recombinant congenic strains of mice.
Alcohol.: Clin. Exp. Res., 23: 61A.
- Ehringer, M., Thompson, J., Xu, Y., Yang, F., Beeson, M., Gordon, L., Bennett,
B., Johnson,T. E., and Sikela, J. M., 1999 High throughput sequencing of candidate
genes for alcohol-related QTLs. Alcohol.: Clin. Exp. Res., 23:
105A.
- Wick, M. J., Whatley, V. J. Johnson,T. E., Erwin, W. J., and Harris, R.
A., 1999 Differentially expressed mRNA species in a congenic mouse model of
alcohol preference/avoidance. Alcohol.: Clin. Exp. Res., 23:
106A.
- Johnson, T. E., Murakami, S., Tedesco, P., Cypser, J., deCastro, E. and
Link C., 1999 Uncovering the secrets of aging using genetics in the nematode
C. elegans. Proceedings of the 22nd Annual Meeting of the Japanese
Society of Biomedical Gerontology. Japan.
- Johnson, T.E., Bennett, B. Sikela, J., Ehringer, M. Xu, Y. and Wick, M.,
2000 Uncovering genes for neurosensitivity to ethanol and general anesthetics.
Keystone Meetings on Alcohol Action, Lake Tahoe, NV.
- Yashin, A., Cypser, J.R., Johnson, T.E., Michalski, A., Boyko, S., 1999
Stress and longevity: a statistical modeling perspective. Abstracts of the
Population Association of America.
- Shen, E. H. and Johnson, T. E., 2000 Provisional QTLs in common for ethanol
and anesthetic sensitivity. Keystone Meetings on Alcohol Action, Lake Tahoe,
NV.
- Owens, J., Bennett B., and Johnson, T. E., 2000 Specification of ataxia,
hypothermia, and locomotor activation of Lores-1, -2,and -5
using Lore Congenics. Keystone Meetings on Alcohol Action, Lake Tahoe, NV.
- Johnson, T. E., 2000 From QTL to Gene. Workshop at the RSA meetings, Denver,
CO.
- Yashin, A.I., Cypser, J. R., Johnson, T.E., Michalski, A.I., Boyko, S. I.,
and Novoseltcev, V. N., 2000 Aging and survival after different doses of heat
shock: the results of analysis of data from stress experiments with the nematode
Caenorhabditis elegans. European Conference on Biogerontology, St-Petersburg,
Russia.
- Owens, J. C., Bennett, B., and Johnson, T. E., 2000 Pleiotropy for hypnotic
sensitivity to ethanol and ethanol-induced locomotor activation using Lore-1
congenics. Alcohol.: Clin. Exp. Res., 24: 97A.
- Ehringer, M., Thompson, J., Conroy, O., Xu, Y., Yang, F., Canniff, J., Beeson,
M., Gordon, L., Bennett, B., Johnson, T.E., Sikela, J. M., 2000 High-throughput
sequencing of candidate genes for alcohol-related QTLs. Alcohol.: Clin.
Exp. Res., 24: 98A.
- Rikke, B.A, Simpson, V. J., Montoliu, L., Johnson, T. E., 2000 No effect
of albinism on sensitivity to ethanol and general anesthetics. Alcohol.:
Clin. Exp. Res., 24: 58A.
- Shen, E.H. and Johnson, T. E., 2000 QTLs in common for ethanol and anesthetic-induced
loss of righting reflex, Alcohol.: Clin. Exp. Res., 24: 97A.
- Bennett, B. and Johnson, T. E., 2000 Confirmation of QTLs for ethanol sleep
time using congenic and recombinant congenic mice. Alcohol.: Clin. Exp.
Res., 24: 96A.
- Yashin, A.I., Cypser, J.W., Johnson, T.E., Michalski, A.I., Boyko, S.I.
and Novoseltcev, V.N., 2000 Stress, aging and longevity: experimental data
and models, The Gerontologist, in press.
- Ehringer, M., Thompson, J., Conroy, O., Xu, Y., Yang, F., Canniff, J., Beeson,
M., Gordon, L., Bennett, B., Goldman, D., Schuckit, M., Johnson, T. E., and
Sikela, J. M., 2000 Progress toward gene identification for alcohol-related
phenotypes. Amer Soc. Human Genet., 67:329.
- Lund, J., Tedesco, P., Duke, K., Kim, S. K. and Johnson, T. E., 2001 Global
profile of gene expression during aging. Abstracts of the 2001 Gordon Research
Conference, Oxford, U.K.
- MacLaren, E., Ehringer, M., Kaiser, A., Yang, F., Soriano, B., Bennett,
B. Johnson, T.E. and Sikela, J.M., 2001 Genomic approaches to the identification
of gene coding region and regulatory differences in QTL candidate genes for
alcohol sensitivity. Alcohol.: Clin. Exp. Res., 25: 117A.
- Johnson, T. E. and Bennett. B., 2001 Phenotypic confirmation of QTLs for
ethanol sleep time and blood ethanol concentration using congenic and congenic
recombinant strains of mice. Alcohol.: Clin. Exp. Res., 25:
117A.
- Owens J. C. and Johnson, T. E., 2001 A classical genetic analysis of low
dose ethanol-induced activation in the inbred long sleep (ILS) and inbred
short sleep (ISS) mice. Alcohol.: Clin. Exp. Res., 25: 116A.
- Proctor, W. R., Bennett, B., Johnson, T. E., and Dunwiddie, T. V., 2001
The ethanol sensitivity of evoked GABAa responses in hippocampal neurons from
congenic lines of mice. Alcohol.: Clin. Exp. Res., 25: 11A.
- Cypser, J. R. and Johnson, T. E., 2001, C. elegans as a model for hormetic
life extension. J. Amer. Aging Assoc., page number not available
- Eisenman, L. M., Donovan, H. S. and Johnson, T. E. Effect of alcohol on
c-fos expression in hypothalamus of LS and SS mice. Abstracts of the 2001
Neuroscience Meetings.
- Lund, J., Tedesco. P., Duke, K., Kim, S. K. and Johnson, T. E., 2001 Global
profile of gene expression during aging. Abstracts of the 13th International
C. elegans Meeting, #241.
- de Castro, E., de Castro, S. H. and Johnson., T. E., 2001 Identification
of genes involved in oxidative stress response and aging in Caenorhabditis
elegans. Abstracts of the 13th International C. elegans Meeting,
#856.
- Owens, J. C., Bennett, B., and Johnson, T. E., 2001 Differential responses
to ethanol-induced activity and ethanol-induced hypothermia in the ILS.ISS.Lore
congenics. Abstracts of the 2001 Neuroscience Meetings.
- Cypser, J. R. and Johnson, T. E., 2002 Using C. elegans to model
induced stress resistance and life span hormesis. Non-linear dose-response
relationships in biology, toxicology and medicine.
- Bennett. B., Johnson, T. E. and Williams, R. W., 2002 A new panel of recombinant
inbred strains from ILS and ISS. Alcohol.: Clin. Exp. Res., 26:
99A.
- Bennett. B., and Johnson, T. E., 2002 Genetic dissection of QTLs for ethanol
sleep time using interval specific congenic recombinant lines of mice. Alcohol.:
Clin. Exp. Res., 26: 99A.
- Haughey, H. M., Kaiser, A. J., Hall, J. T., Johnson, T. E., Bennett, B.,
Sikela, J. M. and Zahniser, N. R., 2002 Norepinephrine transporter expression
influences initial ethanol sensitivity in inbred short-sleep and long-sleep
mice. Alcohol.: Clin. Exp. Res., 26:104A.
- Kaiser, A.L., Yang. Y., Burger, S., Bennett, B., Beeson, M., Gordon, L.,
Johnson, T.E., Sikela, J.M., 2002 High throughput sequencing of the Lore5
initial sensitivity to alcohol QTL in ILS and ISS mice. Alcohol.: Clin.
Exp. Res., 26: 55A.
- Haughey, H. M., Kaiser, A. J., Hall, J. T., Johnson, T. E., Bennett, B.,
Sikela J. and Zahniser, N. R., 2002 The norepinephrine transporter influences
initial ethanol sensitivity in Inbred short-sleep and long-sleep mice. Abstracts
of the 2002 Society for Neurosciences Meetings, 104A.
- Bennett, B., Johnson, T. E., Williams, R. W., 2002 A New Panel of Recombinant
Inbred Strains from ILS and ISS. Complex Trait Consortium Abstracts, Memphis
TN, May, 2002.
- Bennett, B. and Johnson, T.E. 2003 A new panel of recombinant inbred strains
from ILS and ISS. Alcohol.: Clin. Exp. Res. 27: 49A
- Kaiser, A., MacLaren, E., Marshall, K., Walter, N., Bennett, B., Johnson
T.E. and Sikela, J.M., 2003 Identification of an altered coding region between
ILS and ISS mice for Brp17, a candidate gene for the Lore1 QTL. Alcohol.:
Clin. Exp. Res. 27: 48A.
- Downing, C., Hall, J., Springett, J. and Johnson, T. E. 2003 Effects of
the metabotropic glutamate receptor subtype 5 on the sedative-hypnotic properties
of ethanol. Alcohol.: Clin. Exp. Res. 27: 84A.
- Kearns R, Downing, C., Bowman, M., Bennett, B., Johnson T. & Miles
M.F. 2004 Identification of ethanol QTL candidate genes by expression profiling
in ISS/ILS congenic mice. Alcohol.: Clin. Exp. Res. 28:8A
- Bennett, B., Williams, R.W., Lu, L., Gu, J., Carosone-Link, P., Rikke,
B., and Johnson T.E. 2004 Genetic mapping for ethanol-related behaviors in
the LXS panel of recombinant inbred strains from ILS and ISS. Alcohol.:
Clin. Exp. Res. 28:87A
- Parker, C., Carosone-Link, P., Johnson, T.E., and Bennett B. 2004 Ethanol-mediated
anxiety reduction in Inbred Long-Sleep and Inbred Short-Sleep mice on the
elevated zero maze: a pilot study. Alcohol.: Clin. Exp. Res. 28:90A
- Bennett, B., Downing, C., Haughey, H., Zahniser, N., Miles, M., and Johnson,
T. E. 2004 Multistage genetic mapping for ethanol sensitivity: from mapmaker
to candidate genes. Alcohol.: Clin. Exp. Res. 28:63A.
- Johnson, T., Arum, O., Henderson, S., Kahn, N., Rea, S., Tedesco, P., and
Wu, D. 2004 Metabolism and stress resistance in age mutants of C. elegans.
Abstracts of the American Aging Association, p. 8.
- Rikke, B., Johnson, T.E. 2004 Genetic dissection of dietary restriction.
Abstracts of the American Aging Association, p. 78.
- Bennett, B., Carosone-Link, P., Rikke, B., and Johnson, T.E. 2004 Genetic
mapping for ethanol-related behaviors in the LXS panel of recombinant inbred
strains from ILS and ISS. Complex Trait Consortium Abstracts, Bar Harbor,
Maine.
- Miles, M.F., Kerns, R., Downing, C. and Johnson, T. E. 2005 Congenic lines,
expression profiling and bioinformatic approaches define candidate genes for
lore QTLs in ILS/ISS mice. Alcohol.: Clin. Exp. Res. 29:197A
- Kerns, R., Downing, C., Bowman, M. Johnson, T. and Miles, M.F. 2005 Identification
of ethanol QTL candidate genes by expression profiling in ISS/ILS congenic
mice. Alcohol.: Clin. Exp. Res. 29:90A
- Parker, C., Henderson, H., Carosone-Link, P., Holmes, A., Spencer, R.,
Bennett, B., and Johnson, T. E. 2005 The effects of acute and chronic restraint
stress on sensitivity to ethanol-induced loss of righting reflex in inbred
long-sleep, inbred short-sleep, and F1 mice. Alcohol.: Clin. Exp. Res. 29:8A
- Downing, D. and Johnson, T.E. 2005 The metabotropic glutamate receptor
subtype 5 (mGluR5) mediates sensitivity to ethanol-induced sedation. Alcohol.:
Clin. Exp. Res. 29:8A
- Rea, S. L., Kahn, N. Link, C., and Johnson, T. E. SKN-1 Anti oxidant Activity
and Mit Mutant Longevity. Abstracts of the 15th International C. elegans
Meeting p. 128.
- Johnson, T.E., Rea, S., Wu, D., and Cypser, J. 2005 Stochastic effects make a big difference in how long you will live (if you are a worm). Abstracts of the 15th International C. elegans Meeting, p. 186.
- Johnson, T. E., de Grey, A. D. N. J., Fuber, J. D., and Thoman, M. Progress toward postponement of mammalian aging. The Gerontologist, page number not available.
- Downing, C., Bennett, B., Carosone-Link, P.,and Johnson, T.E. 2006 QTL Mapping for the psychomotor stimulant effect of alcohol in LXS recombinant inbred mice. Alcohol.: Clin. Exp. Res. 30: 121A.
- Downing, C., Gaudreau, C., Gilliam, D., and Johnson, T.E. 2006 Effects of prenatal alcohol exposure on activity in mice from four inbred strains. Alcohol.: Clin. Exp. Res. 30: 232A.
- Bennet, B., Carosone-Link, P., and Johnson, T.T. 2006 Confirmation and fine mapping of QTLs for ethanol sensitivity using the LSX RI strains. Alcohol.: Clin. Exp. Res. 30: 121A.
- Miles, M.F., Vorster, P., Downing, C., Bennett, B., and Johnson, T.E., 2006 Identification of ethanol-responsive gene networks by expression profiling across LXS Recombinant Inbred Lines. Alcohol.: Clin. Exp. Res. 30: 177A.
- Parker, C.C., Ponicsan, H., Spencer, R., Holmes, A., and Johnson, T.E., 2006 genetic differences in the effects of acute and chronic forced swim stress on sensitivity to ethanol-induced loss of righting reflex in inbred mice. Alcohol.: Clin. Exp. Res. 30: 123A.
- Gaudreau, C., Gilliam, D.M., Johnson, T.E. and Downing,.C. 2007 Ethanol teratogenesis in inbred long-sleep, inbred short-sleep and C57BL/6J mice. Alcohol.: Clin. Exp. Res. 31: 104A.
- Bennett, B., Carosone-Link, P., and Johnson. T.E. 2007 Mining SNP databases to narrow QTL intervals and identify candidate genes. Alcohol.: Clin. Exp. Res. 31: 134A.
- Downing, C., Miles, M.F., Bennett, B., Sikela, J., Hopkins, J. and Johnson, T.J. 2007 Hypocretin effects on loss of righting due to ethanol (LORE). Alcohol.: Clin. Exp. Res. 31: 191A.
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