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1 Models for G $\times $ E Interactions

The models described in this section are appropriate for analyzing G $\times $ E interaction when genes and environment are acting independently. However, if there is genotype - environment correlation, then more sophisticated statistical procedures are necessary for the analysis. One way of detecting a G - E correlation is to compute the cross-correlations between one twin's environment and the trait of interest in the cotwin (Heath et al., 1989b). If the cross-correlation is not significant, there is no evidence for a G - E correlation, and the G $\times $ E analysis may proceed using the methods described below.


Jeff Lessem 2002-03-21