List of gerontogenes found in the nematode-worm Caenorhabditis elegans
black = published, red = unpublished | ||||
gene | chromosome | life span/WT | Longevity reference | Comment |
age-1 | II | 1.6 | Klass 1983 abstract, Friedman & Johnson 1988 abstract | |
age-2 | I | 1.2 | Yang and Wilson, 1999 abstract | longer-lived at higher temperature |
age-n | Keightley et al., 2000 abstract | |||
age-n(a) | 2000 East Coast C. elegans Meeting abstract 136 | suppressor of daf-16 shortivity | ||
age-n(b) | 2000 East Coast C. elegans Meeting abstract 136 | suppressor of daf-16 shortivity | ||
che-2 | X | 1.4 | Apfeld & Kenyon 1999 abstract | |
che-3 | I | 2 | Apfeld & Kenyon 1999 abstract | |
che-11 | V | 1.4 | Apfeld & Kenyon 1999 abstract | |
che-13 | I | 1.3 | Apfeld & Kenyon 1999 abstract | |
clk-1 | III | 1.4 | Lakowski & Hekimi 1996 abstract | |
clk-2 | III | 1.1 | Lakowski & Hekimi 1996 abstract | |
clk-3 | II | 1.2 | Lakowski & Hekimi 1996 abstract | |
ctl-1 | II | Taub et al., 1999 abstract | required for age-1 Age but not for twp-1 Age | |
daf-2 | III | 2 | Kenyon 1993 abstract | |
daf-5 | II | 2000 East Coast C. elegans Meeting abstract 43 | only one allele was Age | |
daf-6 | X | 1.3 | Apfeld & Kenyon 1999 abstract | |
daf-10 | IV | 1.6 | Apfeld & Kenyon 1999 abstract | |
daf-12;daf-2 | X | 3.4 | Larsen et al., 1995 abstract | strongly allele-specific |
daf-19 | II | 1.3 | Apfeld & Kenyon 1999 abstract | SOMEONE is doing chip work on daf-19 |
daf-21[hsp90] | V | 1.5 | 1999 International C. elegans Meeting abstract 524 | hsp90 |
daf-28 | V | 1.1 | Malone et al., 1996 abstract | |
des-1 | 1.6 | Herndon & Driscoll, 2000 (no abstract available) | ||
eat-1 | IV | 1.3 | Lakowski and Hekimi 1998 abstract | |
eat-2 | II | 1.4 | Lakowski and Hekimi 1998 abstract | |
eat-6 | V | 1.4 | Lakowski and Hekimi 1998 abstract | |
eat-13 | X | 1.3 | Lakowski and Hekimi 1998 abstract | |
eat-18 | I | 1.4 | Lakowski and Hekimi 1998 abstract | |
efk-1 | III | 1.25 | 1999 International C. elegans Meeting abstract 830 | Elongation Factor 2 Kinase homolog |
gro-1 | IV | 1.2 | Lakowski & Hekimi 1996 abstract | |
ins-18 | 1 | ~1.2 | Kawano et al., 2000 abstract | T28B8.3 (authors also use "Ceinsulin-1") |
itt-n(a) | Walker et al., 1998a,b abstract | |||
itt-n(b) | Walker et al., 1998a,b abstract | |||
itt-n/HG25 | 1.2 | Yang and Wilson, 2000 abstract | ||
itt-n/HG96 | 1.5 | Yang and Wilson, 2000 abstract | ||
itt-n/HG246 | 1.3 | Yang and Wilson, 2000 abstract | ||
mec-8 | I | 1.6 | Apfeld & Kenyon 1999 abstract | |
old-1 | II | 2 | Murakami and Johnson 1998 abstract | |
osm-1 | X | 1.4 | Apfeld & Kenyon 1999 abstract | |
osm-3 | IV | 1.6 | Apfeld & Kenyon 1999 abstract | |
osm-5 | X | 2.2 | Apfeld & Kenyon 1999 abstract | |
osm-6 | V | 1.6 | Apfeld & Kenyon 1999 abstract | |
pdk-1 | X | 1.6 | Paradis et al., 1999 abstract | Daf-c |
rad-8 | I | 1.3 | Ishii et al., 1994 abstract | Only at 16oC |
spe-10 | V | 1.4 | Cypser and Johnson, 1999 abstract | |
spe-26 | IV | 1.6 | Van Voorhies 1992 abstract | Supressible by daf-16, but no known Daf |
tax-4 | III | 1.9 | Apfeld & Kenyon 1999 abstract | |
unc-4 | II | 4 | Gems et al., 2000 abstract | male-specific, but JC finds herms strongly Itt |
unc-13 | I | 2.9 | Gems et al., 2000 abstract | male-specific |
unc-26 | IV | 1.5 | Lakowski and Hekimi 1998 abstract | Eat phenotype |
unc-31 | IV | 1.3 | Ailon et al., 1999 abstract | Daf-c |
unc-32 | III | 2.8 | Gems et al., 2000 abstract | male-specific |
unc-64 | III | 1.8,2.4 | Ailon et al., 1999 abstract, Gems et al., 2000 abstract | NOT male-specific |
unc-76 | V | 1.4 | Gems et al., 2000 abstract | male-specific |
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