Component I: Susceptibility Loci: Adolescent Polysubstance
This component is a whole-genome search for chromosomal loci containing
genes influencing early-onset dependence on drugs, with an emphasis on
replicating our initial finding of a suggestive susceptibility locus on
Principal Investigator: Thomas
K. Hewitt , Michael
During the first five years of the center, beginning
in 1997, we accomplished the following highlights for Component I:
- Remained consistently ahead of schedule for recruiting
and obtaining DNA and/or core assessments from substance-dependent adolescents
with serious conduct problems, their siblings and parents.
- By Spring 2001 provided a phenotyped, genotyped, and
cleaned sample of 192 proband-sib pairs for a genome-wide linkage scan.
- At the June 2001 meeting of CPDD reported the first
QTL for adolescent multi-substance dependence.