Component VI: Pilot Projects
This component is designed to permit the Center’s investigators to explore new research possibilities rapidly with small-scale pilot projects and draw other Colorado researchers into this field by supporting pilot projects that advance the aims of the center.
Principal Investigator: Soo Hyun Rhee
From 2003 to 2007, a total of eight pilot projects were recruited.
- Marissa Ehringer – Targeting SNPs in the CNR1 gene for marijuana association study: Year 1
- Marissa Ehringer – Targeting SNPs in the CNR1 gene for marijuana association study: Year 2
- Christian Thurstone – The role of fatty acid hydrolase in adolescent cannabis dependence
- Gary Stetler – An association study of serotonin receptor (5HTR1B) polymorphisms in subjects with conduct and substance abuse disorders
- Marilyn Coors – Ethical issues in substance use disorder genetics
- Brett Haberstick - COMT and disinhibited behavioral problems
- Soo Hyun Rhee – Sex differences in substance use disorders
- Matthew McQueen – INSIG2 gene and obesity- and alcohol-related phenotypes
During the first five years of the center, beginning
in 1997, we accomplished the following highlights for Component VI:
- Supported 5 non-treatment pilot projects.
- Began investigating the relationship and validity of parent vs. child
reports for ADHD as they relate to substance dependence.
- Collected pilot data on the characteristics of a criminal justice
sample to assess the heritability of substance use disorders in this
- Established a dopamine-related genetic association with an early indicator
of behavioral disinhibition.
- Documented the relationship of drug use and sex risk behaviors in
an adolescent substance-abusing sample.
- Examined spousal resemblance for antisocial peronality disorder and
substance dependence among parents of patients and controls.