Component II: Familial Aggregation of Antisocial Substance Dependence
Antisocial behavior and substance use disorders develop and change over
time. In order to better understand the influences on these vulnerabilites,
component II is a follow-up assessment of families of adolescents formerly
in treatment for substance dependence and conduct disorder, and community
control adolescents and their families (matched for gender, age, ethnicity
and residential location).
Principal Investigator: Michael
P. Corley, Soo Rhee
During the first five years of the center, beginning
in 1997, we accomplished the following highlights for Component II:
- Recruited and obtained core assessments and DNA samples from 259 treatment
families and 115 control families (1447 individuals); expects to complete
273 treatment families and 200 control families (approximately 1850
individuals) by the end of the first 5-year funding cycle.
- Established that the community control sample is representative of
other population-based samples; these data (in conjunction with Component
III and Component IV community samples) have been used to operationalize
age- and sex- norms for our primary variables.
- Developed methodology for combining clinical and control families
in joint family pedigree analyses that provide a powerful analytical
design for understanding familial and genetic influences on SUD and
comorbid psychopathology; the methods have been extended to make use
of non-normal psychiatric symptom counts.
- Demonstrated substantial familial aggregation for SUD and comorbid
psychiatric disorders; family influences transmitted from parents to
children (including heritable influences) account for a substantial
proportion of the observed familial resemblance; comorbidity is due
in large part to common familial influences (i.e., generalized risk).
- Demonstrated that marital assortment for SUD and antisocial behavior
is substantial and should be considered when evaluating parent-offspring
and sibling resemblance.