Center for the Genetics and Treatment of Drug Dependence

Mx Scripts for the Joint Analysis of Selected and Unselected Samples


Soo Rhee programs for Neale & Kendler (1995) comorbidity analyses

SAS programs for data simulation

These files are SAS programs that simulate data for the 13 alternative comorbidity models described by Neale and Kendler (1995). For each comorbidity model, there is a program that simulates data for MZ twin pairs and a program that simulates data for DZ twin pairs. These programs create data that can be analyzed by the Mx programs testing the 13 comorbidity models. They can be altered to simulate datasets with different sets of model parameters.

Chance model - chmzck.sas (MZ's); chdzck.sas (DZ's)
Alternate Forms model - altmzck.sas (MZ's); altdzck.sas (DZ's)
Random Multiformity model - rmultmzck.sas (MZ's); rmultdzck.sas (DZ's)
Random Multiformity of A model - rmaddmzck.sas (MZ's); rmadddzck.sas (DZ's)
Random Multiformity of B model - rmcdmzck.sas (MZ's); rmcddzck.sas (DZ's)
Extreme Multiformity model - emultmzck.sas (MZ's); emultdzck.sas (DZ's)
Extreme Multiformity of A model - emaddmzck.sas (MZ's); emadddzck.sas (DZ's)
Extreme Multiformity of B model - emcdmzck.sas (MZ's); emcddzck.sas (DZ's)
Three Independent Disorders model - tdmzck.sas (MZ's); tddzck.sas (DZ's)
Correlated Liabilities model - clmzck.sas (MZ's); cldzck.sas (DZ's)
A causes B model - atobmzck.sas (MZ's); atobdzck.sas (DZ's)
B causes A model - btoamzck.sas (MZ's); btoadzck.sas (DZ's)
Reciprocal Causation model - recmzck.sas (MZ's); recdzck.sas (DZ's)

Mx programs for comorbidity data analysis

These files are Mx programs that test 12 alternative comorbidity models described by Neale and Kendler (1995) by jointly analyzing data from a clinical sample of adolescents treated for antisocial substance problems (202 probands and 272 siblings) and a matched control sample (202 controls matched to the probands and 313 siblings).  The programs in these files examine the comorbidity between alcohol dependence and illicit drug dependence.

chance model - ch.mx
alternate forms model - af.mx
random multiformity model - rm.mx
random multiformity of amodel - rma.mx
random multiformity of b model - rmb.mx
extreme multiformity model - em.mx
extreme multiformity of a model - ema.mx
extreme multiformity of b model - emb.mx
three independent disorder model - td.mx
correlated risk factors model - cr.mx
a causes b model - acb.mx
b causes a model - bca.mx

Supplemental material for Soo Hyun Rhee et al.papers on comorbidity

Tables for Rhee, S.H., Hewitt, J.K., Corley, R.P., & Stallings. M.C. (2003). "The validity of analyses testing the etiology of comorbidity between two disorders: A review of family studies" Journal of Child Psychology and Psychiatry and Allied Disciplines, 44 (4), 612-636.

The following are more detailed versions of Table 2 and 3 of a review paper examining family studies of comorbidity, "The validity of analyses testing the etiology of comorbidity between two disorders: A review of family studies".

Appendix in WORD format - Tables 2 and 3

Table for Rhee, S.H., Hewitt, J.K., Corley, R.P., & Stallings. M.C. (2003)."The validity of analyses testing the etiology of comorbidity between two disorders: Comparisons of disorder prevalences in families". Behavior Genetics, 33 (3), 257-269.

The following is a more detailed version of Table IV of the paper titled "The validity of analyses testing the etiology of comorbidity between two disorders: Comparisons of disorder prevalences in families".

Appendix in WORD format - Table IV for WORD
Appendix in PDF format - Table IV in PDF

Supplemental tables for "The validity of the Neale and Kendler model fitting approach in examining the etiology of comorbidity".
By Rhee, S. H., Hewitt, J. K., Lessem, J. M., Stallings, M. C., Corley, R. P., & Neale, M. C. (2004) Behavior Genetics, 34, 251-265

This appendix presents results of a series of simulations testing data generated under one of 13 comorbidity models against each of the 13 models using three different sets of parameters.

Appendix in WORD format - Supplemental Tables

Table of simulation results for "Testing hypotheses regarding the causes of comorbidity: Examining the underlying deficits of comorbidity disorders." By Rhee, S. H., Hewitt, J. K., Corley, R. P., Willcutt, E. G., & Pennington, B. F. (2005) Journal of Abnormal Psychology, 114, 346-362

This appendix presents the summary results for each of a series of simulations comparing familial correlations for comorbid disorders generated under one of 13 comorbidity models.

Appendix in WORD format - Supplemental Table


Models and results discussed in "The inclusion of measured covariates in the Neale and Kendler model fitting approach." By Rhee, S. H., Neale, M. C., Corley, R. C., and Hewitt, J. K. Manuscript submitted for publication.

Models -

Chance model - ch.mx
Alternate forms model - alt.mx
Random multiformity model - rmult.mx
Random multiformity of a model - rma.mx
Random multiformity of b model - rmb.mx
Extreme multiformity model - emult.mx
Extreme multiformity of a model - ema.mx
Extreme multiformity of b model - emb.mx
Three independent disorders model - td.mx
Correlated liabilities model - cl.mx
A causes b model - atob.mx
B causes a model - btoa.mx
Reciprocal causation model - rec.mx

Results -

Chance model - ch.mxo
Alternate forms model - alt.mxo
Random multiformity model - rmult.mxo
Random multiformity of a model - rma.mxo
Random multiformity of b model - rmb.mxo
Extreme multiformity model - emult.mxo
Extreme multiformity of a model - ema.mxo
Extreme multiformity of b model - emb.mxo
Three independent disorders model - td.mxo
Correlated liabilities model - cl.mxo
A causes b model - atob.mxo
B causes a model - btoa.mxo
Reciprocal causation model - rec.mxo

Data -

Data for control group - control.dat
Data for clinical group - clinical.dat