Soo Rhee programs for Neale & Kendler (1995) comorbidity analyses

These files are SAS programs that simulate data for the 13 alternative comorbidity
models described by Neale and Kendler (1995). For each comorbidity model,
there is a program that simulates data for MZ twin pairs and a program that
simulates data for DZ twin pairs. These programs create data that can be
analyzed by the Mx programs testing the 13 comorbidity models. They can
be altered to simulate datasets with different sets of model parameters.

Chance model - chmzck.sas (MZ's);
chdzck.sas (DZ's)

Alternate Forms model - altmzck.sas (MZ's);
altdzck.sas (DZ's)

Random Multiformity model - rmultmzck.sas (MZ's);
rmultdzck.sas (DZ's)

Random Multiformity of A model - rmaddmzck.sas
(MZ's);
rmadddzck.sas (DZ's)

Random Multiformity of B model - rmcdmzck.sas
(MZ's);
rmcddzck.sas (DZ's)

Extreme Multiformity model - emultmzck.sas
(MZ's);
emultdzck.sas (DZ's)

Extreme Multiformity of A model - emaddmzck.sas
(MZ's);
emadddzck.sas (DZ's)

Extreme Multiformity of B model - emcdmzck.sas
(MZ's);
emcddzck.sas (DZ's)

Three Independent Disorders model - tdmzck.sas
(MZ's);
tddzck.sas (DZ's)

Correlated Liabilities model - clmzck.sas (MZ's);
cldzck.sas (DZ's)

A causes B model - atobmzck.sas (MZ's);
atobdzck.sas (DZ's)

B causes A model - btoamzck.sas (MZ's);
btoadzck.sas (DZ's)

Reciprocal Causation model - recmzck.sas (MZ's);
recdzck.sas (DZ's)

** **

These files are Mx programs that test 12 alternative comorbidity models described by Neale and Kendler (1995) by jointly analyzing data from a clinical sample of adolescents treated for antisocial substance problems (202 probands and 272 siblings) and a matched control sample (202 controls matched to the probands and 313 siblings). The programs in these files examine the comorbidity between alcohol dependence and illicit drug dependence.

chance model - ch.mx

alternate forms model - af.mx

random multiformity model - rm.mx

random multiformity of amodel - rma.mx

random multiformity of b model - rmb.mx

extreme multiformity model - em.mx

extreme multiformity of a model - ema.mx

extreme multiformity of b model - emb.mx

three independent disorder model - td.mx

correlated risk factors model - cr.mx

a causes b model - acb.mx

b causes a model - bca.mx

**
**

The following are more detailed versions of Table 2 and 3 of a review paper examining family studies of comorbidity, "The validity of analyses testing the etiology of comorbidity between two disorders: A review of family studies".

Appendix in WORD format - Tables 2 and 3The following is a more detailed version of Table IV of the paper titled "The validity of analyses testing the etiology of comorbidity between two disorders: Comparisons of disorder prevalences in families".

Appendix in WORD format - Table IV for WORDAppendix in PDF format - Table IV in PDF

**
**

By Rhee, S. H., Hewitt, J. K., Lessem, J. M., Stallings, M. C., Corley, R. P., & Neale, M. C. (2004)

This appendix presents results of a series of simulations testing data generated under one of 13 comorbidity models against each of the 13 models using three different sets of parameters.

Appendix in WORD format - Supplemental Tables

**
**

This appendix presents the summary results for each of a series of simulations comparing familial correlations for comorbid disorders generated under one of 13 comorbidity models.

Appendix in WORD format - Supplemental Table

Chance model - ch.mx

Alternate forms model - alt.mx

Random multiformity model - rmult.mx

Random multiformity of a model - rma.mx

Random multiformity of b model - rmb.mx

Extreme multiformity model - emult.mx

Extreme multiformity of a model - ema.mx

Extreme multiformity of b model - emb.mx

Three independent disorders model - td.mx

Correlated liabilities model - cl.mx

A causes b model - atob.mx

B causes a model - btoa.mx

Reciprocal causation model - rec.mx

Chance model - ch.mxo

Alternate forms model - alt.mxo

Random multiformity model - rmult.mxo

Random multiformity of a model - rma.mxo

Random multiformity of b model - rmb.mxo

Extreme multiformity model - emult.mxo

Extreme multiformity of a model - ema.mxo

Extreme multiformity of b model - emb.mxo

Three independent disorders model - td.mxo

Correlated liabilities model - cl.mxo

A causes b model - atob.mxo

B causes a model - btoa.mxo

Reciprocal causation model - rec.mxo

Data for control group - control.dat

Data for clinical group - clinical.dat